VU 0469650 hydrochloride - CAS 1443748-47-7
Category: Inhibitor
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Molecular Formula:
C22H28N4O.HCl
Molecular Weight:
400.94
COA:
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Targets:
mGluR
Description:
VU 0469650 hydrochloride is a potent and selective negative allosteric modulator of mGlu1 (IC50 = 99 nM), displaying >100-fold selectivity for mGlu1 over mGlu2-8 and 68 other GPCRs, ion channels, kinases and transporters.
Brife Description:
negative allosteric modulator of mGlu1
Purity:
≥98% by HPLC
Synonyms:
VU 0469650 hydrochloride, VU 0469650 HCl, VU 0469650, VU0469650, VU-0469650; 3-[(3R)-3-Methyl-4-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-1-piperazinyl]-2-pyridinecarbonitrile hydrochloride
MSDS:
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InChIKey:
NRWYEXCPHKZKIR-NOCBQHASSA-N
InChI:
InChI=1S/C22H28N4O/c1-15-14-25(20-3-2-4-24-19(20)13-23)5-6-26(15)21(27)22-10-16-7-17(11-22)9-18(8-16)12-22/h2-4,15-18H,5-12,14H2,1H3/t15-,16?,17?,18?,22?/m1/s1
Canonical SMILES:
CC1CN(CCN1C(=O)C23CC4CC(C2)CC(C4)C3)C5=C(N=CC=C5)C#N
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CAS 1443748-47-7 VU 0469650 hydrochloride

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