VU 0422288 - CAS 1630936-95-6
Category: Inhibitor
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Molecular Formula:
C17H11Cl2N3O2
Molecular Weight:
360.19
COA:
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Targets:
mGluR
Description:
VU 0422288 is a group III mGlu receptor positive allosteric modulator (EC50 = 108, 125 and 146 nM for mGlu4, mGlu8 and mGlu7, respectively) with selectivity over a panel of 68 other GPCRs, ion channels and transporters. VU 0422288 has been shown to potentiate mGlu7-mediated reductions in excitatory post synaptic potentials in hippocampal slices.
Brife Description:
group III mGluR positive allosteric modulator
Purity:
≥98% by HPLC
Synonyms:
VU0422288; VU-0422288; VU 0422288; ML 396; ML-396; ML396; N-[3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-2-pyridinecarboxamide
MSDS:
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InChIKey:
MZRLPXFGQKQHST-UHFFFAOYSA-N
InChI:
InChI=1S/C17H11Cl2N3O2/c18-11-4-7-16(21-10-11)24-15-6-5-12(9-13(15)19)22-17(23)14-3-1-2-8-20-14/h1-10H,(H,22,23)
Canonical SMILES:
C1=CC=NC(=C1)C(=O)NC2=CC(=C(C=C2)OC3=NC=C(C=C3)Cl)Cl
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Chemical Structure

CAS 1630936-95-6 VU 0422288

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