|Description||VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displaying weak activity at mGlu5 and mGlu8 receptors, and being inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors.|
|Synonyms||VU 0361737, VU-0361737, VU0361737|
(±)-trans-ACPD has been found to be a mGluR2 agonist.
DCG IV is a potent group II mGluR agonist and a presynaptic depressant.
(S)-4C3H-PG has been found to be a competitive GluR1 glutamate receptor antagonist as well as metabotropic GluR2/3 glutamate receptor agonist.
(±)-LY367385 is a selective mGlu1a antagonist.
The hydrochloride salt form of ACDPP, which has been found to be a mGluR-5 antagonist.
Mavoglurant is a structurally novel, non-competitive mGlu5 receptor antagonist (IC50=30 nM), as a a selective non-competitive antagonist.
CPCCOEt has been found to be a mGluR-1 antagonist.
ML-289 is a negative allosteric modulator of mGlu3 with IC50 value of 0.66 μM. It displays 15-fold selectivity over mGlu2 and inactivity against mGlu5.1.