VU 0155041 - CAS 1093757-42-6
Category: Inhibitor
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Molecular Formula:
C14H15Cl2NO3
Molecular Weight:
316.18
COA:
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Targets:
mGluR
Description:
VU 0155041 is a potent positive allosteric modulator at mGlu4 receptors (EC50 = 798 and 693 nM at human and rat mGlu4 receptors, respectively). VU 0155041 displays no activity for 67 G protein-coupled receptors, ion channels, and transporters, and lacks antagonist activity at NMDA receptors in striatal medium spiny neurons at a concentration of 10 μM. VU 0155041 is active in in vivo models of Parkinson's disease following i.c.v. administration.
Brife Description:
positive allosteric modulator at mGlu4 receptors
Purity:
≥99% by HPLC
Related CAS:
1259372-69-4 (sodium salt)
Synonyms:
VU0155041, VU 0155041, VU-0155041; cis-2-[[(3,5-Dichlorophenyl)amino]carbonyl]cyclohexanecarboxylic acid; (1R,2S)-2-[(3,5-dichlorophenyl)carbamoyl]cyclohexane-1-carboxylic acid
MSDS:
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InChIKey:
VSMUYYFJVFSVCA-NWDGAFQWSA-N
InChI:
InChI=1S/C14H15Cl2NO3/c15-8-5-9(16)7-10(6-8)17-13(18)11-3-1-2-4-12(11)14(19)20/h5-7,11-12H,1-4H2,(H,17,18)(H,19,20)/t11-,12+/m0/s1
Canonical SMILES:
C1CCC(C(C1)C(=O)NC2=CC(=CC(=C2)Cl)Cl)C(=O)O
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Chemical Structure

CAS 1093757-42-6 VU 0155041

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