|Description||Venetoclax is a small-molecule inhibitor that has high selectivity for Bcl-2 (Ki < 0.01 nM in cell-free assays) over Mcl-1. It suppresses anti-apoptotic Bcl-2, a protein commonly overexpressed in cancer cells, to induce programmed death of CLL cells. Venetoclax is used as a second-line treatment of chronic lymphocytic leukemia (CLL).|
|B0084-462638||500 mg||$298||In stock|
|Brife Description||Bcl-2 inhibitor, chronic lymphocytic leukemia (CLL)|
|Solubility||10mM in DMSO|
|Application||the treatment of chronic lymphocytic leukemia (CLL)|
|Shelf Life||2 years|
|Current Developer||AbbVie; Genentech|
WEHI-539 hydrochloride is a selective inhibitor of Bcl-XL (IC50= 1.1 nM) with high affinity and selectivity for BCL-XL and potently kills cells by selectively a...
(+)-Apogossypol is a potent inhibitor of Bcl-2 family proteins, binding and inhibiting Bcl-2 and Bcl-X(L) with high affinity and induces apoptosis of tumor cell...
AT-101 acetic acid
AT101 acetic acid is orally bioavailable solvate of R-(-)-enantiomer of gossypol with potential antineoplastic activity. It is used as the treatment of non Hodg...
HA14-1 is a potent Bcl-2 inhibitor with potential anticancer activity. HA14-1 induces apoptosis in various human cancer cells. HA14-1 suppressed NF-kappaB activ...
ML311, also known as EU-5346, is a potent and selective inhibitor of the Protein-Protein Interaction of Mcl-1 and Bim. EU-5346 inhibits proliferation of Her2-po...
A-1155463, an effective and selective BCL-XL inhibitor, has been studied to have probable effect in restraining the growth of small cell lung cancer xenograft t...
Mcl1-IN-2, a hydroxyquinoline derivative, is an Mcl-1 inhibitor.
Bax inhibitor peptide V5
Bax inhibitor peptide V5, a peptide inhibitor, as a pro-apoptotic member of Bcl-2 family proteins and plays an important role in mitochondria-dependent apoptosi...
Muristerone A, a phytoecdysteroid analog of ecdysone, acts as an inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals...
BDA-366 is a BCL2-BH4 antagonist(Ki=3.3nM) which suppresses human myeloma growth. BDA-366 induces apoptosis in MM cell lines and primary MM cells by inducing BC...
S-63845 is a selective inhibitor of MCL1 (Ki (MCL1, FP) < 1.2 nM; Kd (MCL1, SPR) = 0.19 nM; Ki (BCL2, FP) > 10.000 1.2 nM; Ki (BCL-XL, FP) > 10.000 1.2 nM). It ...
Venetoclax is a small-molecule inhibitor that has high selectivity for Bcl-2 (Ki < 0.01 nM in cell-free assays) over Mcl-1. It suppresses anti-apoptotic Bcl-2, ...
CID5721353 is a B-Cell Lymphoma 6 Inhibitor (BCL6 inhibitor) that disrupts BCL6/corepressor complexes in vitro and in vivo, and was shown to bind the critical s...
(S)-Gossypol acetic acid
(S)-Gossypol acetic acid, a Bcl-2 inhibitor, could effectively induce the death of Jurkat cells in which Bcl-2 or Bcl-xL is overexpressed. IC50: 18.1μM and 22.9...
UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family.
ABT-737 is a potent, cell-permeable mimetic of BH3 domains that avidly binds Bcl-2, Bcl-xL, and Bcl-W (Ki < 1 nM for all three proteins). It blocks the interact...
Marinopyrrole A, a new Mcl-1 inhibitor, could influence Mcl-1-Bim interaction and induce the degradation of Mcl-1 proteasomal and also lead to the apoptosis of ...
FX1 is a selective inhibitor of B cell lymphoma 6 (BCL6) (IC50 = 35 μM in reporter assays), which can disrupt formation of the BCL6 repression complex, reactiva...
BAM 7 is a direct and selective activator of proapoptotic Bax with EC50 of 3.3 μM.
Mcl1-IN-1 is a potent Mcl-1-selective inhibitor with IC50 of 2.4 uM, relative to the related Bcl-2 family protein Bcl-xL.