Velneperit - CAS 342577-38-2
Catalog number: 342577-38-2
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C17H24F3N3O3S
Molecular Weight:
407.45
COA:
Inquire
Targets:
Neuropeptide Y receptor
Description:
Velneperit is a once-daily, oral, centrally acting, small molecule neuropeptide Y (NPY) Y5 receptor antagonist.
Purity:
≥98%
Appearance:
White to Off-White Solid
Synonyms:
S-2367; S 2367; S2367; VelneperitN-[5-(Trifluoromethyl)pyridin-2-yl]-trans-4-(tert-butylsulfonylamino)cyclohexane-1-carboxamide;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
An optimized synthetic neuropeptide Y (NPY) Y5 receptor antagonist used in the oral treatment of obesity.
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Melting Point:
223-224 °C
Density:
1.31 g/cm3
InChIKey:
WGEWUYACXPEFPO-UHFFFAOYSA-N
InChI:
1S/C17H24F3N3O3S/c1-16(2,3)27(25,26)23-13-7-4-11(5-8-13)15(24)22-14-9-6-12(10-21-14)17(18,19)20/h6,9-11,13,23H,4-5,7-8H2,1-3H3,(H,21,22,24)
Canonical SMILES:
CC(C)(C)S(=O)(=O)NC1CCC(CC1)C(=O)NC2=NC=C(C=C2)C(F)(F)F
1.New and emerging drug molecules against obesity.
George M1, Rajaram M, Shanmugam E. J Cardiovasc Pharmacol Ther. 2014 Jan;19(1):65-76. doi: 10.1177/1074248413501017. Epub 2013 Sep 24.
Obesity has become a growing pandemic of alarming proportions in the developed and developing countries over the last few decades. The most perturbing fact regarding obesity is the increased predisposition for coronary artery disease, congestive heart failure and sudden cardiac death. The modest efficacy of current anti-obesity agents such as orlistat and the increasing withdrawals of several anti-obesity agents such as sibutramine, rimonabant have led to huge gaps in the pharmacotherapy of obesity. Lorcaserin and Phentermine-topiramate combination (phen-top) are two drugs approved by US FDA in 2012. Lorcaserin, a 5HT2C agonist has moderate efficacy with an acceptable safety profile. Clinical trials with Phen-top have shown a reasonable efficacy but at the cost of risks such as teratogenicity and psychiatric disturbances. Cetilistat, a lipase inhibitor is claimed to have superior safety profile to orlistat and is in phase 3 clinical trials.
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