|Description||Vatalanib succinate is a potent and orally bioactive VEGFR inhibitor (IC50 =37 and 77 nM for VEGFR-2 and -1, respectively) exhibiting potential antineoplastic activity. Vatalanib binds to the protein kinase domain of VEGFR, and inhibits proliferation, migration and survival of HUVECs in vitro. Vatalanib also inhibits PDGFR-β, c-Kit and c-Fms.|
|Brife Description||VEGFR inhibitor|
|Purity||≥99% by HPLC|
|Related CAS||212141-51-0 (hydrochloride); 212141-54-3 (free base)|
|Synonyms||N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine succinate; CGP 79787D; PTK 787; ZK 222584; CGP79787D; PTK787; ZK222584; CGP-79787D; PTK-787; ZK-222584|
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