Vardenafil hydrochloride - CAS 224785-91-5
Catalog number: 224785-91-5
Category: Inhibitor
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Molecular Formula:
C23H33ClN6O4S
Molecular Weight:
525.06
COA:
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Targets:
Phosphodiesterase (PDE)
Description:
A phsphodiesterase 5 inhibitor.
Purity:
>98%
Synonyms:
Vivanza hydrochloride; Levitra hydrochloride
MSDS:
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InChIKey:
XCMULUAPJXCOHI-UHFFFAOYSA-N
InChI:
InChI=1S/C23H32N6O4S.ClH/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28;/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30);1H
Canonical SMILES:
CCCC1=NC(=C2N1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)CC)OCC)C.Cl
1.Validated spectrofluorimetric method for determination of two phosphodiesterase inhibitors tadalafil and vardenafil in pharmaceutical preparations and spiked human plasma.
Abu El-Enin MA1, Al-Ghaffar Hammouda Mel-S1, El-Sherbiny DT1, El-Wasseef DR1, El-Ashry SM1. Luminescence. 2016 Feb;31(1):173-8. doi: 10.1002/bio.2941. Epub 2015 May 27.
A valid, sensitive and rapid spectrofluorimetric method has been developed and validated for determination of both tadalafil (TAD) and vardenafil (VAR) either in their pure form, in their tablet dosage forms or spiked in human plasma. This method is based on measurement of the native fluorescence of both drugs in acetonitrile at λem 330 and 470 nm after excitation at 280 and 275 nm for tadalafil and vardenafil, respectively. Linear relationships were obtained over the concentration range 4-40 and 10-250 ng/mL with a minimum detection of 1 and 3 ng/mL for tadalafil and vardenafil, respectively. Various experimental parameters affecting the fluorescence intensity were carefully studied and optimized. The developed method was applied successfully for the determination of tadalafil and vardenafil in bulk drugs and tablet dosage forms. Moreover, the high sensitivity of the proposed method permitted their determination in spiked human plasma. The developed method was validated in terms of specificity, linearity, lower limit of quantification (LOQ), lower limit of detection (LOD), precision and accuracy.
2.Cardiac factors affecting the success of vardenafil in erectile dysfunction.
Zengin K, Ede H, Tanik S, Albayrak S, Sarikaya S, Erbay A, Imamoğlu MA, Gürdal M. Turk J Med Sci. 2015;45(4):751-7.
BACKGROUND/AIM: To evaluate the predictability of vardenafil success in patients with erectile dysfunction (ED) by using cardiological tests.
3.Simultaneous Detection of Three Phosphodiesterase Type 5 Inhibitors and Eight of Their Analogs in Lifestyle Products and Screening for Adulterants by High-Performance Thin-Layer Chromatography.
Do TT, Theocharis G, Reich E. J AOAC Int. 2015 Sep-Oct;98(5):1226-33. doi: 10.5740/jaoacint.14-285.
An HPTLC method is proposed to permit effective screening for the presence of three phosphodiesterase type 5 inhibitors (PDE5-Is; sildenafil, vardenafil, and tadalafil) and eight of their analogs (hydroxyacetildenafil, homosildenafil, thiohomosildenafil, acetildenafil, acetaminotadalafil, propoxyphenyl hydroxyhomosildenafil, hydroxyhomosildenafil, and hydroxythiohomosildenafil) in finished products, including tablets, capsules, chocolate, instant coffee, syrup, and chewing gum. For all the finished products, the same simple sample preparation may be applied: ultrasound-assisted extraction in 10 mL methanol for 30 min followed by centrifugation. The Rf values of individual HPTLC bands afford preliminary identification of potential PDE5-Is. Scanning densitometry capabilities enable comparison of the unknown UV spectra with those of known standard compounds and allow further structural insight. Mass spectrometric analysis of the material derived from individual zones supplies an additional degree of confidence.
4.Thermal Analysis Investigation of Dapoxetine and Vardenafil Hydrochlorides using Molecular Orbital Calculations.
Attia AK1, Souaya ER2, Soliman EA1. Adv Pharm Bull. 2015 Nov;5(4):523-9. doi: 10.15171/apb.2015.071. Epub 2015 Nov 30.
PURPOSE: Thermal analysis techniques have been used to study the thermal behavior of dapoxetine and vardenafil hydrochlorides and confirmed using semi-empirical molecular orbital calculations.
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CAS 224785-91-5 Vardenafil hydrochloride

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