Valganciclovir hydrochloride - CAS 175865-59-5
Catalog number: B0084-061144
Category: Inhibitor
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Molecular Formula:
C14H23ClN6O5
Molecular Weight:
390.82
COA:
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Targets:
CMV
Description:
Valganciclovir hydrochloride hydrate is an antiviral used to treat cytomegalovirus infection. It is the prodrug of ganciclovir, a synthetic analog of 2'-deoxy-guanosine which is phosphorylated to a dGTP analog that competitively inhibits the incorporation of dGTP by viral DNA polymerase.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-061144 2.5 g $168 In stock
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Purity:
>98%
Synonyms:
RS 079070-194; Ro 107-9070/194; Valcyte; (S)-Valganciclovir Hydrochloride
MSDS:
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InChIKey:
ZORWARFPXPVJLW-MTFPJWTKSA-N
InChI:
InChI=1S/C14H22N6O5.ClH/c1-7(2)9(15)13(23)24-4-8(3-21)25-6-20-5-17-10-11(20)18-14(16)19-12(10)22;/h5,7-9,21H,3-4,6,15H2,1-2H3,(H3,16,18,19,22);1H/t8?,9-;/m0./s1
Canonical SMILES:
CC(C)C(C(=O)OCC(CO)OCN1C=NC2=C1NC(=NC2=O)N)N.Cl
1. Ocular complications after kidney transplantation: a case report and review of literature
Zihret Abazi • Lidija Magarasevic • Svetlana Sukalo • Natalija Kosanovic-Jakovic • Dusica Risovic. Int Urol Nephrol (2014) 46:665–668
The medical history of a 45-year-old female revealed a long-standing history of MPGN II, which was confirmed by a kidney biopsy in 2001. Due to the end-stage renal disease after hemodialysis, she received cadaveric kidney transplantation in 2012. A rare peripheral drusen-like deposit is occurred in the third decade of life. The regular annual ophthalmic examinations showed no progression of ocular manifestations. The preoperative ophthalmic findings revealed rare drusen-like deposits in the posterior pole, while findings of the anterior segment were normal. The best-corrected visual acuity (BCVA) was 6/6 in both eyes. After renal transplantation, time-zero graft biopsy was not performed due to a limited subcapsular hematoma in the inferior pole. She received polyclonal antibody (rATG) induction, followed by methylprednisolone, tacrolimus, and mycophenolate mofetil. Valganciclovir hydrochloride and trimethoprim-sulfamethoxazole were administered for cytomegalovirus and bacterial prophylaxis, respectively. Doppler ultrasonography was performed in which adequate renal perfusion and normal graft characteristics were observed. Three months after her kidney transplantation, ophthalmic findings were unchanged.
2. Oral valganciclovir as preemptive therapy is effective for cytomegalovirus infection in allogeneic hematopoietic stem cell transplant recipients
Katsuto Takenaka, Tetsuya Eto, Koji Nagafuji , Kenjiro Kamezaki. Int J Hematol (2009) 89:231–237
Valganciclovir hydrochloride (VGC) is an oral valineester GCV prodrug with a tenfold higher bioavailability than oral GCV, and it is rapidly hydrolyzed to GCV after oral administration. Valganciclovir hydrochloride (VGC) and IV-GCV have similar efficacy in the treatment of CMV retinitis in HIV-infected patients and in preemptive CMV treatment in solid organ (heart, renal, and renal-pancreas) transplant patients. Recently, several studies have shown the efficacy of Valganciclovir hydrochloride (VGC) for preemptive therapy in allogeneic HSCT patients. We evaluated the safety and efficacy of oral Valganciclovir hydrochloride (VGC) as preemptive therapy for CMV reactivation in ten allogeneic HSCT patients.
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