|Description||Valerenic acid is a positive allosteric modulator of GABAA receptors displaying selectivity for receptors containing β2 or β3 subunits. Valerenic acid exhibits sedative, anticonvulsant and anxiolytic effects in vivo. Valerenic acid also acts as a partial agonist of 5-HT5A receptors.|
|Brife Description||positive allosteric modulator of GABAA receptors|
|Purity||≥99% by HPLC|
SB 205384 is a GABAA receptor modulator. SB 205384 potentiates α6, α3 and α5-subunit-containing receptors (EC50 = 280, 695 and 730 nM, respectively). It exhibit...
Etifoxine, also called as HOE 36801 or Stresam, is a positive allosteric modulator of GABAreceptors that produces anxiolytic effects by preferentially modulatin...
CH-50911 is a selective GABA-B antagonist with IC50 value of 1.1 μM. It is developed by Schering-Plough Corporation. CH-50911 is often used in pharmacology rese...
Lorediplon is a hypnotic drug acting as a GABAA receptor modulator, differentially active at the alpha1-subunit. It is a novel nonbenzodiazepine of the pyrazolo...
(-)-Bicuculline methobromide is the methobromide salt of (+)-bicuculline, which is a potent antagonist of GABAA receptors.
A GABAA receptor modulator that effects against anxiety.
2-Hydroxysaclofen is a GABAB receptor antagonist.
RuBi GABA trimethylphosphine is the modified version of RuBi-GABA, which inhibits neural activity in vivo and is suitable for use as alternative for GABA agonis...
TCS 1105 is a GABAA benzodiazepine receptor (BZR) ligand that acts as an agonist at α2 and antagonist at α1 benzodiazepine receptors (Ki = 118 and 245 nM, respe...
(±)-Nipecotic acid is a nonselective GAT inhibitor that also induces GABA release through a process termed 'heteroexchange. IC50 = 8, 38, 106 and 2370 μM for hG...
NS 11394 is a drug with selectivity for the α3 and α5 subtypes. It acts as a subtype-selective positive allosteric modulator at GABAA receptors. It is used as a...
PZ-II-029,a pyrazoloquinolinone, was reported as the first postitive modulator of GABAA α6β3γ2 subtype functionally selective ligands to date.
SR 95531 hydrobromide
SR 95531 hydrobromide is a competitive GABAA receptor antagonist. SR 95531 differs from bicuculline that it selectively antagonizes GABA-induced Cl- currents bu...
SKF 97541 is a highly potent GABAB agonist, and also acts as a GABAA-ρ antagonist. SKF 97541 exhibits sedative effects in mammals and has the potential to be us...
L-Cycloserine is excitatory amino acid, an antibiotic effective against Mycobacterium tuberculosis.
CGP 55845 hydrochloride
CGP 55845 hydrochloride is a potent and selective GABAB receptor antagonist (IC50 = 5 nM), which prevents agonist binding (pKi = 8.35) and inhibits release of G...
Pregnenolone sulfate sodium salt
Pregnenolone sulfate, a metabolite of the natural steroid hormone pregnenolone, is a neurosteroid that has been demonstrated to antagonize the GABAA receptor ch...
AA 29504 is a positive allosteric modulator of GABAA receptors with anxiolytic activity. It modulates both α4β3δ-containing extrasynaptic receptors and α1β3γ2S-...
CL 218872 has been found to be a benzodiazepine agonist and has been found to exhibit anxiolytic and anticonvulsant activities.
U 93631 is a ligand at the picrotoxin site of GABA(A) receptors, allosterically antagonizing GABA-induced Cl- currents. U-93631 causes rapid decay of gamma-amin...