Valacyclovir hydrochloride - CAS 124832-27-5
Catalog number: 124832-27-5
Category: Inhibitor
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Molecular Formula:
C13H20N6O4.HCl
Molecular Weight:
360.8
COA:
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Targets:
HSV
Description:
Valaciclovir HCl is an antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B.
Purity:
>98%
Synonyms:
N/A
MSDS:
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InChIKey:
ZCDDBUOENGJMLV-QRPNPIFTSA-N
InChI:
InChI=1S/C13H20N6O4.ClH/c1-7(2)8(14)12(21)23-4-3-22-6-19-5-16-9-10(19)17-13(15)18-11(9)20;/h5,7-8H,3-4,6,14H2,1-2H3,(H3,15,17,18,20);1H/t8-;/m0./s1
Canonical SMILES:
CC(C)C(C(=O)OCCOCN1C=NC2=C1NC(=NC2=O)N)N.Cl
1.Herpes Mastitis: Diagnosis and Management.
Toussaint A1,2, Simonson C1, Valla C2. Breast J. 2016 Feb 21. doi: 10.1111/tbj.12579. [Epub ahead of print]
Herpetic lesions most frequently occur on oral and genital areas. However, herpes simplex virus (HSV) can be a rare cause of breast infection. In few published articles, the route of transmission is predominantly from infant to mother. We report two cases about simultaneous mammary and extramammary (oral and genital) herpetic infection in nonlactating women. In both cases, HSV breast lesions were acquired by sexual contacts with partners who were asymptomatic HSV carriers. Through a review of literature, we highlight clinical signs for an early diagnosis. We also emphasize the advantage of the valacyclovir for treating this uncommon pathology.
2.A rare complication of follicular hair unit extraction: Kaposi's varicelliform eruption.
Mansur AT1, Demirci GT1, Uzunismail MA2, Yildiz S3. Dermatol Pract Concept. 2016 Jan 31;6(1):15-7. doi: 10.5826/dpc.0601a05. eCollection 2016.
Follicular hair unit extraction (FUE) is becoming a popular type of hair transplantation recently. Kaposi's varicelliform eruption (KVE) is an uncommon skin emergency due to cutaneous dissemination of several types of viruses, most notably herpes virus, over the lesions of preexisting skin disorders. A 34-year-old man visited our dermatology outpatient clinic with a blistering, itchy and tender eruption on his head and body. He had undergone follicular FUE for androgenic alopecia 12 days previously, and 5 days after the procedure, umbilicated and/or hemorrhagic vesiculopustules appeared firstly on the occipital scalp skin where the hair units were taken. The lesions had rapidly spread over the upper chest and back. After the operation, he had taken oral methylprednisolone, amoxicillin clavulanate and had used fusidic acid ointment without any benefit. Bacterial culture of the pustules yielded no microorganism, while Tzanck smear from the vesicles revealed multinuclear giant cell groups.
3.Relationship between prior knowledge about herpes zoster and the period from onset of the eruption to consultation in patients with herpes zoster.
Miyachi M1, Imafuku S1. J Dermatol. 2016 Mar 12. doi: 10.1111/1346-8138.13334. [Epub ahead of print]
Herpes zoster (HZ) is a common internal infection caused by latent varicella zoster virus. Emergence of antiviral chemotherapy has changed the treatment of HZ dramatically, but the effects of such therapy are documented only in patients who started treatment within 72 h of HZ onset of the eruption. There have been few studies addressing the question of factors that determine early attendance of patients at a clinic. We questioned 256 patients with acute HZ about: (i) date from onset of the eruption to first clinic visit; and (ii) their prior knowledge of HZ. We found a tendency that patients who already knew about HZ had consulted dermatology clinics earlier (P < 0.05). People most commonly obtained information about the disease from friends and family members who had previously had HZ, but not from the Internet or other mass media. Our results indicate that patient education is important for early attendance at dermatology clinics, which in turn, should result in the improved outcome of antiviral chemotherapy and prevention of postherpetic neuralgia.
4.In Utero Treatment of Congenital Cytomegalovirus Infection with Valacyclovir in a multicentre, open-label, phase II study.
Leruez-Ville M1, Ghout I2, Bussières L3, Stirnemann J4, Magny JF5, Couderc S6, Salomon LJ4, Guilleminot T1, Aegerter P2, Benoist G7, Winer N8, Picone O9, Jacquemard F10, Ville Y4. Am J Obstet Gynecol. 2016 Apr 12. pii: S0002-9378(16)30044-8. doi: 10.1016/j.ajog.2016.04.003. [Epub ahead of print]
BACKGROUND: Congenital infection with human cytomegalovirus (CMV) is a major cause of morbidity and mortality. A randomized controlled trial (RCT) showed that high-dosage valacyclovir prevents CMV disease in transplant recipients. Fetuses showing ultrasound features of infection are at high risk of being symptomatic at or before birth. In a pilot study, oral administration of high-dosage valacyclovir to mothers significantly decreased viral load and produced therapeutic concentrations in the blood of infected fetuses. An RCT comparing prenatal treatment with valacyclovir against placebo in infected fetuses failed to recruit because women declined randomization. RCTs in fetal medicine have often proven unacceptable by women who decline termination of pregnancy (TOP) and are not prepared to resign themselves to the odds of the natural history of the disease.
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CAS 124832-27-5 Valacyclovir hydrochloride

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