Uvaol - CAS 545-46-0
Catalog number: 545-46-0
Not Intended for Therapeutic Use. For research use only.
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Molecular Weight:
Uvaol, also called urs-12-ene-3β,28-diol is a natural triterpenoid found in the herbs of Callicarpa bodinieri Levl. Urs-12-ene-3β,28-diol exhibits the activity of anti-inflammatory. Urs-12-ene-3β,28-diol also has has anti-proliferative activity,inhibits the angiotensin II-induced proliferation in a PPAR-γ-dependent manner, while at high doses they activate pathways of programmed cell death that are dependent on JNK and PPAR-γ.
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anti-inflammatory; anti-proliferative
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Enterprise Standard
1.05 g/cm3
1.Phytochemical and biological evaluation of Buddleja polystachya growing in Saudi Arabia.
Al Ati HY1, Fawzy GA2, El Gamal AA3, Khalil AT4, El Din El Tahir K5, Abdel-Kader MS6, Gilani AH7. Pak J Pharm Sci. 2015 Jul;28(4 Suppl):1533-40.
Several Buddleja species were the target of phytochemical and biological studies; however, nothing was reported concerning the chemistry of Buddleja polystachya Fresen. growing in Saudi Arabia. Sixteen constituents were isolated from the aerial parts of B. polystachya using various chromatographic techniques and were identified by the help of different spectral techniques including 1D, 2D NMR and mass spectrometry. Moreover, the different fractions were evaluated for their anti-inflammatory and hypoglycemic activities. The isobenzofuranone derivative (4-hydroxy-7-methylisobenzofuranone) (4), has been isolated for the first time from this natural source, B. polystachya, along with fifteen known compounds namely; phenolic fatty acid ester, 1'(4-hydroxyphenyl) ethanol ester of docosanoic (1), uvaol (2), sakuranetin (3), kumatakenin (5), cirsimaritin (6), 5-hydroxy-3,7,4'-trimethoxyflavone (7), oleanolic acid (8), herbacetin 3,7,8-trimethyl ether (9), ursolic acid (10), verbascoside (11), linarin (12), luteolin 7-O-β-D-glucoside (13), luteolin 7-(6"-caffeoyl)-O-β-D-glucopyranoside (14), luteolin (15), and 6-O-α-L-(4''-O-trans-cinnamoyl) rhamnopyranosylcatalpol (16).
2.Tetra- and Penta-Cyclic Triterpenes Interaction with Lipid Bilayer Membrane: A Structural Comparative Study.
Abboud R1,2, Charcosset C2, Greige-Gerges H3. J Membr Biol. 2016 Jan 13. [Epub ahead of print]
The effect of tetracyclic (cortisol, prednisolone, and 9-fluorocortisol acetate) and pentacyclic (uvaol and erythrodiol) triterpenes (TTPs) on the fluidity of dipalmitoyl phosphatidyl choline (DPPC) liposome membrane was investigated by differential scanning calorimetry, Raman spectroscopy, and fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene (DPH). Liposomes were prepared in the absence and presence of TTPs at molar ratios DPPC:TTP 100:1, 100:2.5, and 100:10. All the studied TTPs abolished the pre-transition and modified the intensity of the Raman peak at 715 cm-1 proving the interaction of TTP molecules with the choline head group of phospholipids. An increase in the Raman height intensity ratios of the peaks I 2935/2880, I 2844/2880, and I 1090/1130, giving information about the ratio disorder/order of the alkyl chains, and a decrease of the main transition temperature demonstrated the interaction of TTPs with the alkyl chains.
3.[A new cyclic diarylheptanoid from the bark of Myrica rubra].
Shen SN, Xia FB, Li H, Liu YM, Pan RL. Yao Xue Xue Bao. 2015 Jun;50(6):746-8.
To study the chemical constituents from the bark of Myrica rubra, fourteen compounds were isolated from the methanolic extract using various chromatographic techniques, including silica gel, Sephadex LH-20 and preparative HPLC. Their structures were identified on the basis of chemical properties and spectroscopic data, as 3, 5-dimethoxy-4-hydroxymyricanol (1), myricanol (2), myricanone (3), myricanol 11-sulfate (4), myricitrin (5), quercetin (6), quercetin-3-rhamnoside (7), tamarixol (8), uvaol (9), ursolic acid (10), taraxerol (11), myricadiol (12), β-sitosterol (13) and β-daucosterol (14). Among them, compound 1 is a new compound, named as 3, 5-dimethoxy-4-hydroxymyricanol, compounds 8, 9 were isolated from the genus Myrica for the first time.
4.Chemical constituents of Eugenia catharinae and their antioxidant activity.
Moresco HH1, Colla G1, Cavalcante ID1, Queiroz GS1, Pizzolatti MG1, Brighente IM1. Nat Prod Res. 2016 Jan 13:1-5. [Epub ahead of print]
Nine compounds were isolated from the leaves of Eugenia catharinae, namely monomethyl olivetol (1), β-sitosterol (2), stigmasterol (3), uvaol (4), erythrodiol (5), rotundic acid (6), quercetin (7), catechin (8) and myricitrin (9). The structures of 1-9 were established through analysis of their spectroscopic (1H and 13C NMR) and spectrometric (MS) data. Compounds 1 and 6 are reported the first time in the Eugenia genus. In addition, these data were compared with those reported in the literature. The antioxidant activity of plant samples and compounds was measured using the DPPH radical scavenging assay. Flavonoids 7, 8, 9 and the ethanolic extract showed the best results, with IC50 values of 20.94 μM, 44.20 μM, 30.01 μM and 58.82 μg/mL, respectively.
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CAS 545-46-0 Uvaol

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