UNC-2025 - CAS 1429881-91-3
Catalog number: 1429881-91-3
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C28H40N6O
Molecular Weight:
476.669
COA:
Inquire
Targets:
FLT3
Description:
UNC-2025 is a novel potent and highly orally bioavailable Mer/FLT3 dual inhibitor, capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow. Kinome profiling versus more than 300 kinases in vitro and cellular selectivity assessments demonstrate that UNC-2025 has similar subnanomolar activity against Flt3, an additional important target in acute myelogenous leukemia (AML), with pharmacologically useful selectivity versus other kinases examined.
Purity:
0.98
Appearance:
white solid powder
Synonyms:
UNC2025; UNC 2025.
MSDS:
Inquire
InChIKey:
MJSHVHLADKXCML-UHFFFAOYSA-N
InChI:
InChI=1S/C28H40N6O/c1-3-4-13-29-28-30-18-25-26(20-34(27(25)31-28)23-9-11-24(35)12-10-23)22-7-5-21(6-8-22)19-33-16-14-32(2)15-17-33/h5-8,18,20,23-24,35H,3-4,9-17,19H2,1-2H3,(H,29,30,31)
Canonical SMILES:
CCCCNC1=NC=C2C(=CN(C2=N1)C3CCC(CC3)O)C4=CC=C(C=C4)CN5CCN(CC5)C
Current Developer:
University of North Carolina at Chapel Hill
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UNC-2025 hydrochloride

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Chemical Structure

CAS 1429881-91-3 UNC-2025

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