|Description||An indolocarbazole isolated from a high staurosporine-producing streptomyces culture; inhibits protein kinase C (PKC) and cyclin-dependant kinase 2 (CDK2), resulting in accumulation of cells in the G1 phase and induction of apoptosis; also enhances the cytotoxicity of other anti-cancer drugs, such as DNA-damaging agents and anti-metabolite drugs, through putative abrogation of G2 and/or S phase accumulation induced by the latter agents.|
|Purity||>99% by HPLC|
|Solubility||Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.|
Belongs to a novel class of antibiotics, possessing a new terpenylated diketopiperazine structure, with antibiotic, antifungal and anthelmintic activity
The major analogue of a complex of C-glycoside antitumour actives isolated from a streptomyces sp.; contains a vinyl group in the 8-position; an inhibitor of th...
A minor component of the leptomycin complex produced by some streptomyces sp.; an hydroxylated analogue of leptomycin A, a nuclear export inhibitor; displays po...
Leptomycin B, isolated from Streptomyces sp., is a potent and specific nuclear export inhibitor, and class II histone deacetylase inhibitor. Leptomycin B direct...
Ionomycin Calcium Salt
The Calcium Salt of Ionomycin, a kind of polyether antibiotic, has been found to be Gram-positive and often used as a calcium ionophore.
Defined as a mixture of 75% ostreogrycin A (virginiamycin M1) and 25% virginiamycin S1; acts a synergist, binding to the conformational change of the peptidyl t...
A complex family of macrocyclic lactones; a major member of a group of analogues containing a 25-methyl substituent; a highly selective and potent nematocide an...
An unusual anthracycline produced by streptomyces nogalater var. Nogalater; contains two saccharides; a potent antibacterial and antitumor agent that interacts ...
A member of the macrotetrolide complex produced by a range of streptomyces sp.; a monovalent cation ionophore with high selectivity for ammonium and potassium. ...
The oxidised and highly fluorescent analogue of UCN-01 and UCN-02; a potent inhibitor of protein kinase C and formation of cellular blebs induced by phorbols; i...
An antibacterial pigment isolated from streptomyces davawensis; an anti-metabolite of riboflavin; mimic riboflavin in flavin biosynthesis; an important regulato...
A linear, tetracyclic, broad spectrum antibiotic; first prepared chemically by dechlorination of chlortetracycline and subsequently isolated from several strept...
A member of the macrotetrolide complex produced by a range of streptomyces species; a monovalent cation ionophore with high selectivity for ammonium and potassi...
The dominant analogue of a class macrocyclic lactones isolated from selected strains of streptomyces sp.; an inhibitor of mitochondrial F1F0-atpase; induces apo...
Kanamycin acid disulfate
An aminoglycoside antibiotic often used to select for bacteria which have been successfully transformed with a plasmid conferring kanamycin resistance; soluble ...
1,6-dimethoxyphenazine is a simple phenazine produced by several species of streptomyces. Dimethoxyphenazine is a weakly active antibacterial metabolite with ac...
Isolated from streptomyces conglobatus; has a unusual, dimeric, macrolide dilactone structure with pendant oxazole groups; exhibits an IC50 of 0.63 μg/ml in a N...
Isolated from streptomyces conglobatus as a potent gram positive antibiotic; exhibits a very high affinity and selectivity for calcium ions as a calcium ionopho...
A macrolide antibiotic similar in structure to erythromycin
An unusual chain-extended analogue of aureothin; a co-metabolite of neoantimycin in streptomyces orinoci; has anti-HIV and antifungal activity; potent immunosup...