|Description||U 93631 is a ligand at the picrotoxin site of GABA(A) receptors, allosterically antagonizing GABA-induced Cl- currents. U-93631 causes rapid decay of gamma-aminobutyric acid-induced chloride currents in recombinant rat gamma-aminobutyric acid type A receptors.|
|Synonyms||4,5-Dihydro-4,4-dimethyl-imidazo[1,5-a]quinoxaline-3-carboxylic acid 1,1-dimethylethyl ester; U93631, U-93631, U 93631|
|Storage||Store in a cool and dry place (or refer to the Certificate of Analysis).|
|Boiling Point||470.1±45.0 °C at 760 Torr|
CGP7930 is a positive allosteric modulator at the GABAB receptor. It has anxiolytic effects in animal studies, and has a synergistic effect with GABAB agonists ...
CGP 54626 hydrochloride
The hydrochloride salt form of CGP 54626, a dichloropheny derivative, has been found to be a GABAB receptor antagonist that could probably be effective as an an...
This active molecular is a highly selective inverse agonist/negative allosteric modulator GABAAα5 receptors. It was developed by Roche to treat cognitive impair...
Tracazolate hydrochloride is a subtype-selective GABAA receptor modulator that potentiates or inhibits recombinant GABAA function depending on subunit combinati...
U 90042 is a GABAA receptor ligand binding to three receptor subtypes: α1β2γ2, α3β2γ2 and α6β2γ2 (Ki = 7.8, 9.5 and 11.0 nM, respectively). U 90042 potentiates ...
ZAPA sulfate acts as an agonist at low affinity GABAA receptors and is thus a useful ligand to investigate GABA receptors linked to benzodiazepine receptors. ZA...
DMCM hydrochloride is a benzodiazepine inverse agonist exhibiting anxiogenic and potent convulsant activity.
SL 651498 is a GABAA agonist selectively for subtype α2, and has the potential for the treatment of anxiety.