U 89843A - CAS 157013-85-9
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C16H23N5.HCl
Molecular Weight:
321.85
COA:
Inquire
Targets:
GABA Receptor
Description:
U 89843A is a positive allosteric modulator of GABAA receptors. U 89843A potentiates GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 GABAA receptors. U 89843A exhibits sedative activity following i.v. administration without losing "righting reflex" and also displays antioxidant activity.
Brife Description:
allosteric modulator of GABAA receptors
Purity:
≥99% by HPLC
Synonyms:
6,7-Dimethyl-2,4-di-1-pyrrolidinyl-7H-pyrrolo[2,3-d]pyrimidine hydrochloride
MSDS:
Inquire
InChIKey:
MNKBXPNQWKUSKU-UHFFFAOYSA-N
InChI:
InChI=1S/C16H23N5.ClH/c1-12-11-13-14(19(12)2)17-16(21-9-5-6-10-21)18-15(13)20-7-3-4-8-20;/h11H,3-10H2,1-2H3;1H
Canonical SMILES:
CC1=CC2=C(N1C)N=C(N=C2N3CCCC3)N4CCCC4.Cl
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related GABA Receptor Products


CAS 114012-12-3 Phaclofen

Phaclofen
(CAS: 114012-12-3)

Phaclofen, a phosphonic acid derivative of Baclofen, is a selective GABAB antagonist.

CAS 33125-97-2 Etomidate

Etomidate
(CAS: 33125-97-2)

Etomidate is a GABAA receptor agonist, used as a short-acting anaesthetic agent or sedative.

CAS 91917-65-6 Ro 15-4513

Ro 15-4513
(CAS: 91917-65-6)

Ro 15-4513, a high affinity benzodiazepine ligand, acts as a competitive antagonist, and can therefore be an antidote to the acute impairment caused by alcohol....

CAS 128-20-1 Pregnanolone

Pregnanolone
(CAS: 128-20-1)

Pregnanolone, also known as Kabi-2213, SKF 6455, Eltanolone, is a GABAA receptor positive allosteric modulator potentially for the treatment of pain.

CAS 371962-01-5 ZAPA sulfate

ZAPA sulfate
(CAS: 371962-01-5)

ZAPA sulfate acts as an agonist at low affinity GABAA receptors and is thus a useful ligand to investigate GABA receptors linked to benzodiazepine receptors. ZA...

CAS 374084-31-8 DS2

DS2
(CAS: 374084-31-8)

DS2 has been found to be a positive allosteric modulator of δ-GABAA receptors and could probably be useful against analgesics as well as sleep disorders.

CAS 54-95-5 Cardiazole

Cardiazole
(CAS: 54-95-5)

Cardiazole is a GABA(A) receptor antagonist, causes alterations in excitatory and inhibitory neurotransmitter systems.

CAS 60252-41-7 (±)-Nipecotic acid

(±)-Nipecotic acid
(CAS: 60252-41-7)

(±)-Nipecotic acid is a nonselective GAT inhibitor that also induces GABA release through a process termed 'heteroexchange. IC50 = 8, 38, 106 and 2370 μM for hG...

CAS 133737-32-3 Pagoclone

Pagoclone
(CAS: 133737-32-3)

Pagoclone, an active (+)-enantiomer of the racemate RP 59037, is a ubtype selective partial agonist at GABAA receptor and used for the treatment of panic and an...

CAS 207306-50-1 TB 21007

TB 21007
(CAS: 207306-50-1)

TB 21007, as a nootropic drug, is a GABAA receptor inverse agonist selective for the α5-subtype (Ki values are 1.6, 16, 20 and 20 nM for α5, α2, α1 and α3 subty...

CAS 62666-20-0 Progabide

Progabide
(CAS: 62666-20-0)

Progabide is a gamma-aminobutyric acid (GABA) antagonist. It has agonistic activity for both the GABAA and GABAB receptors. It has antiepileptic activity and is...

CAS 21715-46-8 Etifoxine

Etifoxine
(CAS: 21715-46-8)

Etifoxine, also called as HOE 36801 or Stresam, is a positive allosteric modulator of GABAreceptors that produces anxiolytic effects by preferentially modulatin...

CAS 71424-95-8 3-Methyl-GABA

3-Methyl-GABA
(CAS: 71424-95-8)

3-Methyl-GABA is an activator of GABA aminotransferase.

CAS 39069-52-8 GS 39783

GS 39783
(CAS: 39069-52-8)

GS 39783 is an allosteric positive modulator of GABAB receptors, decreases cocaine self-administration, blocks the rewarding properties of nicotine and produces...

CAS 56287-74-2 Afloqualone

Afloqualone
(CAS: 56287-74-2)

Afloqualone is a agonist of GABA receptor has sedative and muscle-relaxant effects.

CAS 38090-53-8 TACA

TACA
(CAS: 38090-53-8)

TACA, the trans-isomer of CACA, is a potent GABAA and GABAC agonist, GABA uptake inhibitor and substrate for GABA-T. It also acts as a GABAA-ρ agonist.

CAS 917393-39-6 Lorediplon

Lorediplon
(CAS: 917393-39-6)

Lorediplon is a hypnotic drug acting as a GABAA receptor modulator, differentially active at the alpha1-subunit. It is a novel nonbenzodiazepine of the pyrazolo...

CAS 840486-93-3 adipiplon

adipiplon
(CAS: 840486-93-3)

Adipiplon is GABAA receptor partial agonist. It can bind to the α3 subtype. Adipiplon is one of the first drugs selected for clinical development which is able ...

CAS 123690-79-9 CGP 35348

CGP 35348
(CAS: 123690-79-9)

CGP 35348 is a selective and brain penetrant GABAB receptor antagonist (IC50 = 34 μM as measured in rat cortical membranes) with higher affinity for postsynapti...

CAS 182485-36-5 TPMPA

TPMPA
(CAS: 182485-36-5)

TPMPA is a selective and competitive GABAA-ρ antagonist with 8-fold selectivity for human recombinant ρ1 receptors over ρ2 receptors. TPMPA exhibits minimal eff...

Chemical Structure

CAS 157013-85-9 U 89843A

Quick Inquiry

Verification code

Featured Items