(-)-U-50488 hydrochloride - CAS 114528-79-9
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
Opioid Receptor
(-)-U-50488 hydrochloride is the more active enantiomer of (±)-U-50488, which is an opioid receptor agonist.
Brife Description:
κ-opioid agonist
≥99% by HPLC
Related CAS:
67198-13-4 (racemic free base); 67197-96-0 (racemic hydrochloride); 114528-81-3 ((+)-enantiomer)
(-)-U-50488 hydrochloride; (-)-U 50488 hydrochloride; (-)-U50488 hydrochloride; trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride; (-)-trans-(1S,2S)-U-50488 hydrochloride
Canonical SMILES:
1.Isopathic versus enantiomeric inhibition of U-50488 HCl toxicity--experimental studies.
Kuzeff RM;Topashka-Ancheva M;Metcheva R Homeopathy. 2009 Apr;98(2):83-7. doi: 10.1016/j.homp.2009.02.002.
BACKGROUND: ;Previous studies have investigated toxicity inhibition of optically active compounds by potentized preparations of their enantiomers. It was hypothesised that inhibition of toxicity may be stereospecific. This paper presents 2 studies investigating stereoisomer potencies in terms of their ability to counteract toxicity of the (-) stereoisomer. The stereoisomers used were (-)-trans-(1S,2S)-U-50488 HCl and (+)-trans-(1R,2R)-U-50488 HCl.;MATERIALS & METHODS: ;Designs were prospective, blind, randomised, intention-to-treat and compared the efficacy of 2 indistinguishable treatments. The outcome was the difference in survival. Potency 'chords' consisting of 4th, 12th and 30th approximately centesimal dilutions were prepared, representing concentrations of 1.08 x 10(-10) M. One study compared inhibition of (-)-U-50488 toxicity injected ip at the estimated LD50 into male ICR mice, treated with a potency chord of the same stereoisomer, with control ('isopathic' study). The other study compared inhibition of toxicity by potency chords made from the stereoisomers (+)-U-50488 and (-)-U-50488 ('enantiomer' study), Treatments were administered orally on 11 occasions: twice before and nine times after ip injections.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Opioid Receptor Products

CAS 849024-68-6 UFP-101

(CAS: 849024-68-6)

UFP-101 is a potent, selective and competitive silent antagonist for the NOP opioid receptor, displaying > 3000-fold selectivity over δ, μ and κ opioid receptor...

CAS 236098-40-1 [Arg14,Lys15]Nociceptin

(CAS: 236098-40-1)

[Arg14,Lys15]Nociceptin behaves as a highly potent agonist of the OP(4) receptor (EC50 = 1 nM) and is able to produce long-lasting effects in vivo, compared wit...

CAS 1354744-91-4 Naloxegol oxalate

Naloxegol oxalate
(CAS: 1354744-91-4)

Naloxegol oxalate is a CYP3A4 enzyme inhibitor, is a peripherally-selective opioid antagonist, for the treatment of opioid-induced constipation.

CAS 34552-83-5 Loperamide HCl

Loperamide HCl
(CAS: 34552-83-5)

Loperamide HCl is an opioid-receptor agonist with an ED50 of 0.15 mg/kg.

CAS 111469-81-9 Naltrindole hydrochloride

Naltrindole hydrochloride
(CAS: 111469-81-9)

Naltrindole hydrochloride is a cell permeable, potent and highly selective non-peptideδ opioid receptor antagonist (Ki= 0.02 nM) with 223- and 346-fold greater ...

CAS 153205-46-0 Asimadoline

(CAS: 153205-46-0)

Asimadoline is a κ opioid receptor agonist with less brain-penetrant ability. Asimadoline is the potential treatment of irritable bowel syndrome.

CAS 114528-81-3 (+)-U-50488 hydrochloride

(+)-U-50488 hydrochloride
(CAS: 114528-81-3)

(+)-U-50488 hydrochloride is the less active enantiomer of (±)-U-50488, which is an opioid receptor agonist.

CAS 357-08-4 Naloxone hydrochloride

Naloxone hydrochloride
(CAS: 357-08-4)

Naloxone HCl is an opioid inverse agonist drug used to counter the effects of opiate overdose.

Chemical Structure

CAS 114528-79-9 (-)-U-50488 hydrochloride

Quick Inquiry

Verification code

Featured Items