(-)-U-50488 hydrochloride - CAS 114528-79-9
Category: Inhibitor
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Molecular Formula:
C19H26Cl2N2O.HCl
Molecular Weight:
405.79
COA:
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Targets:
Opioid Receptor
Description:
(-)-U-50488 hydrochloride is the more active enantiomer of (±)-U-50488, which is an opioid receptor agonist.
Brife Description:
κ-opioid agonist
Purity:
≥99% by HPLC
Related CAS:
67198-13-4 (racemic free base); 67197-96-0 (racemic hydrochloride); 114528-81-3 ((+)-enantiomer)
Synonyms:
(-)-U-50488 hydrochloride; (-)-U 50488 hydrochloride; (-)-U50488 hydrochloride; trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride; (-)-trans-(1S,2S)-U-50488 hydrochloride
MSDS:
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InChIKey:
KGMMGVIYOHGOKQ-APTPAJQOSA-N
InChI:
InChI=1S/C19H26Cl2N2O.ClH/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23;/h8-9,12,17-18H,2-7,10-11,13H2,1H3;1H/t17-,18-;/m0./s1
Canonical SMILES:
CN(C1CCCCC1N2CCCC2)C(=O)CC3=CC(=C(C=C3)Cl)Cl.Cl
1.Isopathic versus enantiomeric inhibition of U-50488 HCl toxicity--experimental studies.
Kuzeff RM;Topashka-Ancheva M;Metcheva R Homeopathy. 2009 Apr;98(2):83-7. doi: 10.1016/j.homp.2009.02.002.
BACKGROUND: ;Previous studies have investigated toxicity inhibition of optically active compounds by potentized preparations of their enantiomers. It was hypothesised that inhibition of toxicity may be stereospecific. This paper presents 2 studies investigating stereoisomer potencies in terms of their ability to counteract toxicity of the (-) stereoisomer. The stereoisomers used were (-)-trans-(1S,2S)-U-50488 HCl and (+)-trans-(1R,2R)-U-50488 HCl.;MATERIALS & METHODS: ;Designs were prospective, blind, randomised, intention-to-treat and compared the efficacy of 2 indistinguishable treatments. The outcome was the difference in survival. Potency 'chords' consisting of 4th, 12th and 30th approximately centesimal dilutions were prepared, representing concentrations of 1.08 x 10(-10) M. One study compared inhibition of (-)-U-50488 toxicity injected ip at the estimated LD50 into male ICR mice, treated with a potency chord of the same stereoisomer, with control ('isopathic' study). The other study compared inhibition of toxicity by potency chords made from the stereoisomers (+)-U-50488 and (-)-U-50488 ('enantiomer' study), Treatments were administered orally on 11 occasions: twice before and nine times after ip injections.
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CAS 114528-79-9 (-)-U-50488 hydrochloride

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