U 18666A - CAS 3039-71-2
Category: Inhibitor
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Molecular Formula:
C25H41NO2.HCl
Molecular Weight:
424.07
COA:
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Targets:
Hedgehog
Description:
U 18666A is a cell-permeable and amphiphilic amino-steroid that inhibits cholesterol synthesis and cellular transport via the suppression of 2,3-oxidosqualene-lanosterol cyclase activity. U 18666A also acts as a weak inhibitor of hedgehog (Hh) signaling. It has been shown to reduce serum sterol levels in rats in vivo.
Brife Description:
cholesterol synthesis and cellular transport inhibitor, hedgehog (Hh) signaling inhibitor
Synonyms:
U-18666A; U 18666A; U18666A; U 18666 A; U-18666-A; NSC-70801; NSC 70801; NSC70801; (3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride
MSDS:
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InChIKey:
GZFYZYBWLCYBMI-MYZJJQSMSA-N
InChI:
InChI=1S/C25H41NO2.ClH/c1-5-26(6-2)15-16-28-19-11-13-24(3)18(17-19)7-8-20-21-9-10-23(27)25(21,4)14-12-22(20)24;/h7,19-22H,5-6,8-17H2,1-4H3;1H/t19-,20-,21-,22-,24-,25-;/m0./s1
Canonical SMILES:
CCN(CC)CCOC1CCC2(C3CCC4(C(C3CC=C2C1)CCC4=O)C)C.Cl
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