|Description||U 18666A is a cell-permeable and amphiphilic amino-steroid that inhibits cholesterol synthesis and cellular transport via the suppression of 2,3-oxidosqualene-lanosterol cyclase activity. U 18666A also acts as a weak inhibitor of hedgehog (Hh) signaling. It has been shown to reduce serum sterol levels in rats in vivo.|
|Brife Description||cholesterol synthesis and cellular transport inhibitor, hedgehog (Hh) signaling inhibitor|
RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.
Ciliobrevin A is a Hedgehog (HH) pathway inhibitor and is a key signaling molecule in HH pathway. It blocked HH pathway activation by SAG, decreased Smo ciliary...
Glasdegib is an orally bioavailable small-molecule inhibitor of the Hedgehog (Hh) signaling pathway that binds to Smoothened (Smo) and inhibits signal transduct...
AY 9944 dihydrochloride
AY 9944 dihydrochloride is the dihydrochloride salt of AY 9944, which is an amphiphilic and cell-permeable diamine and acts as a sonic hedgehog inhibitor. It ma...
RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase) (IC50 = 0.85 µM). RU-SKI 43 is cell-permeable and inhibits both autocrine and paracrin...
SAG 21k is a potent, brain penetrating and orally available activator of Hedgehog signaling (EC50 = 0.4 nM).
HPI 1 is a hedgehog (Hh) signaling inhibitor that blocks Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 = 1.5, 1.5,...
U 18666A is a cell-permeable and amphiphilic amino-steroid that inhibits cholesterol synthesis and cellular transport via the suppression of 2,3-oxidosqualene-l...
AZ 12080282 dihydrochloride is the dihydrochloride salt of AZ 12080282, which is a novel hedgehog antagonist and inhibits towards the SMO receptor affecting emb...
Jervine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling. It is an inhibitor of Smo and derived from th...
NL-103, a nicotinamide derivative, has been found to be an inhibitor of both histone deacetylases and hedgehog pathway. It was found to exhibit activity in decr...
Vismodegib (GDC-0449) is a potent, novel and specific inhibitor of hedgehog with IC50 of 3 nM and also inhibitor of P-gp with IC50 of 3.0 μM.