Tyrphostin A1 - CAS 2826-26-8
Catalog number: 2826-26-8
Category: Inhibitor
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Molecular Formula:
C11H8N2O
Molecular Weight:
184.197
COA:
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Targets:
Interleukin Related
Description:
Tyrphostin A1, can be as a negative control for inhibition of EGFR (IC50 >1250 µM) and was shown to inhibit the tyrosine phosphorylation of IL-2 stimulated Tyk-2 in plemented with 20% LADMAC supernatant.
Appearance:
light yellow crystalline needles or crystals
Synonyms:
Tyrphostin 1; Tyrphostin-1; Tyrphostin1; 2-[(4-methoxyphenyl)methylidene]propanedinitrile(3,4-dihydroxybenzylidene)malononitrile(3,4-dihydroxyphenyl)methylene propanedinitrile3,4-dihydroxybenzylidenemalononitrileRG 50810; RG50810RG-50810tyrphostin 23tyrphostin A1tyrphostin A23tyrphostin AG18tyr
Solubility:
Soluble to 25 mg/ml in ethanol, 25 mg/ml in DMSO, 50 mg/ml in chloroform
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -24℃ for long term (months to years).
MSDS:
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Shelf Life:
2 years
Boiling Point:
352.4±27.0 °C | Condition: Press: 760 Torr
Melting Point:
115 °C
Density:
1.169±0.06 g/cm3
InChIKey:
UOHFCPXBKJPCAD-UHFFFAOYSA-N
InChI:
1S/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3
Canonical SMILES:
COC1=CC=C(C=C1)C=C(C#N)C#N
1.Synthesis, Characterization, and Cytotoxicity of Some New 5-Aminopyrazole and Pyrazolo[1,5-a]pyrimidine Derivatives.
Hassan AS1, Hafez TS1, Osman SA1. Sci Pharm. 2014 Oct 24;83(1):27-39. doi: 10.3797/scipharm.1409-14. eCollection 2015.
5-Amino-N-aryl-3-[(4-methoxyphenyl)amino]-1H-pyrazole-4-carboxamides 4a-c were synthesized by the reaction of N-(aryl)-2-cyano-3-[(4-methoxyphenyl)amino]-3-(methylthio)acrylamides 3a-c with hydrazine hydrate in ethanol. The reaction of 5-amino-N-aryl-1H-pyrazoles 4a-c with acetylacetone 5 or 2-(4-methoxybenzylidene)malononitrile 8 yielded the pyrazolo[1,5-a]pyrimidine derivatives 7a-c and 10a-c, respectively. The structures of the synthesized compounds were established based on elemental analysis and spectral data (IR, MS, (1)H-NMR, and (13)C-NMR). Representative examples of the new synthesized products were screened for their in vitro cytotoxic activity against Ehrlich Ascites Carcinoma (EAC) cells.
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Chemical Structure

CAS 2826-26-8 Tyrphostin A1

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