Turofexorate Isopropyl - CAS 629664-81-9
Catalog number: B0084-221750
Category: Inhibitor
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Molecular Formula:
C25H24F2N2O3
Molecular Weight:
438.47
COA:
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Targets:
FXR
Description:
Turofexorate Isopropyl is a highly potent, selective, and orally active farnesoid X receptor (FXR) agonist.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-221750 25 mg $298 In stock
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Purity:
>98%
Synonyms:
WAY-362450; WAY362450; WAY 362450; XL335; XL 335; XL-335; Turofexorate isopropyl.
MSDS:
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InChIKey:
INASOKQDNHHMRE-UHFFFAOYSA-N
InChI:
InChI=1S/C25H24F2N2O3/c1-14(2)32-24(31)17-12-29(23(30)15-9-10-18(26)19(27)11-15)13-25(3,4)21-16-7-5-6-8-20(16)28-22(17)21/h5-12,14,28H,13H2,1-4H3
Canonical SMILES:
CC(C)OC(=O)C1=CN(CC(C2=C1NC3=CC=CC=C32)(C)C)C(=O)C4=CC(=C(C=C4)F)F
1.Roles of subunit NuoL in the proton pumping coupling mechanism of NADH:ubiquinone oxidoreductase (complex I) from Escherichia coli.
Narayanan M1, Sakyiama JA1, Elguindy MM1, Nakamaru-Ogiso E2. J Biochem. 2016 Apr 26. pii: mvw027. [Epub ahead of print]
Respiratory complex I has an L-shaped structure formed by the hydrophilic arm responsible for electron transfer and the membrane arm that contains protons pumping machinery. Here, to gain mechanistic insights into the role of subunit NuoL, we investigated the effects of Mg2+, Zn2+, and the Na+/H+ antiporter inhibitor 5-(N-ethyl-N-isopropyl)-amiloride (EIPA) on proton pumping activities of various isolated NuoL mutant complex I after reconstitution into E. coli double knockout (DKO) membrane vesicles lacking complex I and the NADH dehydrogenase type 2. We found that Mg2+ was critical for proton pumping activity of complex I. At 2 μM Zn2+, proton pumping of the wild-type was selectively inhibited without affecting electron transfer; no inhibition in proton pumping of D178N and D400A were observed, suggesting the involvement of these residues in Zn2+ binding. 15 μM EIPA caused up to ~40% decrease in the proton pumping activity of the wild-type, D303A and D400A/E, while no significant change was detected in D178N, indicating its possible involvement in the EIPA binding.
2.Light-induced gene expression with photocaged IPTG for induction profiling in a high-throughput screening system.
Wandrey G1, Bier C2, Binder D3, Hoffmann K1, Jaeger KE3,4, Pietruszka J2,4, Drepper T3, Büchs J5. Microb Cell Fact. 2016 Apr 23;15(1):63. doi: 10.1186/s12934-016-0461-3.
BACKGROUND: Inducible expression systems are frequently used for the production of heterologous proteins. Achieving maximum product concentrations requires induction profiling, namely the optimization of induction time and inducer concentration. However, the respective experiments can be very laborious and time-consuming. In this work, a new approach for induction profiling is presented where induction in a microtiter plate based cultivation system (BioLector) is achieved by light using photocaged isopropyl β-D-1-thiogalactopyranoside (cIPTG).
3.Overexpression of Heat Shock Factor Gene HsfA3 Increases Galactinol Levels and Oxidative Stress Tolerance in Arabidopsis.
Song C1, Chung WS1,2, Lim CO1,2. Mol Cells. 2016 Apr 25. doi: 10.14348/molcells.2016.0027. [Epub ahead of print]
Heat shock factors (Hsfs) are central regulators of abiotic stress responses, especially heat stress responses, in plants. In the current study, we characterized the activity of the Hsf gene HsfA3 in Arabidopsis under oxidative stress conditions. HsfA3 transcription in seedlings was induced by reactive oxygen species (ROS), exogenous hydrogen peroxide (H2O2), and an endogenous H2O2 propagator, 2,5-dibromo-3-methyl-6-isopropyl-p-benzoquinone (DBMIB). HsfA3-overexpressing transgenic plants exhibited increasedoxidative stress tolerance compared to untransformed wild-type plants (WT), as revealed by changes in fresh weight, chlorophyll fluorescence, and ion leakage under light conditions. The expression of several genes encoding galactinol synthase (GolS), a key enzyme in the biosynthesis of raffinose family oligosaccharides (RFOs), which function as antioxidants in plant cells, was induced in HsfA3 overexpressors. In addition, galactinol levels were higher in HsfA3 overexpressors than in WT under unstressed conditions.
4.Cobalt catalyzed peroxymonosulfate oxidation of tetrabromobisphenol A: Kinetics, reaction pathways, and formation of brominated by-products.
Ji Y1, Kong D2, Lu J3, Jin H1, Kang F1, Yin X1, Zhou Q1. J Hazard Mater. 2016 Apr 14;313:229-237. doi: 10.1016/j.jhazmat.2016.04.033. [Epub ahead of print]
Degradation of tetrabromobisphenol A (TBBPA), a flame retardant widely spread in the environment, in Co(II) catalyzed peroxymonosulfate (PMS) oxidation process was systematically explored. The second-order-rate constant for reaction of sulfate radical (SO4-) with TBBPA was determined to be 5.27×1010M-1s-1. Apparently, degradation of TBBPA showed first-order kinetics to the concentrations of both Co(II) and PMS. The presence of humic acid (HA) and bicarbonate inhibited TBBPA degradation, most likely due to their competition for SO4-. Degradation of TBBPA was initiated by an electron abstraction from one of the phenolic rings. Detailed transformation pathways were proposed, including β-scission of isopropyl bridge, phenolic ring oxidation, debromination and coupling reactions. Further oxidative degradation of intermediates in Co(II)/PMS process yielded brominated disinfection by-products (Br-DBPs) such as bromoform and brominated acetic acids.
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CAS 629664-81-9 Turofexorate Isopropyl

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