Triptolide - CAS 38748-32-2
Not Intended for Therapeutic Use. For research use only.
Category:
ADCs
Product Name:
Triptolide
Catalog Number:
38748-32-2
Synonyms:
PG490
CAS Number:
38748-32-2
Description:
Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii.
Molecular Weight:
360.4
Molecular Formula:
C20H24O6
COA:
Inquire
MSDS:
Inquire
Tag:
ADCs Cytotoxin
Chemical Structure
CAS 38748-32-2 Triptolide

Related ADCs Cytotoxin Products


Penetran Cl

Synthetic, an inhibitor of high-affinity choline uptake (HAChU) in synaptosomes.

CAS 142948-19-4 Scyllatoxin

Scyllatoxin
(CAS: 142948-19-4)

Scyllatoxin (also leiurotoxin I) is a toxin, from the scorpion Leiurus quinquestriatus hebraeus, which blocks small-conductance Ca2+-activated K+ channels.

CAS 216064-36-7 β-Pompilidotoxin

β-Pompilidotoxin
(CAS: 216064-36-7)

β-Pompilidotoxin slows the inactivation of neuronal Navs. β-Pompilidotoxin was isolated from the venoms of two wasps, Anoplius amariensis and Batozonellus macul...

Acorine
(CAS: 110225-59-7)

A C20-diterpene alkaloid, reversible N-cholinoblocker A Diterpene alkaloid Isolated from the epigeal part ofAconitum coreanum.

1-Benzoylnapelline
(CAS: 198126-85-1)

Derivative of Napelline. Napelline isolated from plant Aconitum karakolicum Diterpenoid Alkaloid Synthesized from Napelline. Napelline is extracted from Aconitu...

Sevedindione

Sevedindione presents an antiarrhythmic activity on arrhythmias caused by Aconitine.

CAS 25316-40-9 Doxorubicin hydrochloride

Doxorubicin hydrochloride
(CAS: 25316-40-9)

Doxorubicin (Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis.

Imperialine iodomethylate

A highly active peripheral M2-cholinoblocker alkaloid. Imperialine is extracted from Petilium eduardi and Petilium raddeanae (Liliaceae family)

CAS 304-21-2 Harmaline

Harmaline
(CAS: 304-21-2)

Harmaline is a fluorescent psychoactive indole alkaloid from the group of harmala alkaloids and beta-carbolines. It is the partially hydrogenated form of harmin...

CAS 364-98-7 Diazoxide

Diazoxide
(CAS: 364-98-7)

Diazoxide is a potassium channel activator that causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. The cellular rel...

Bj-xtrlT (recombinant)

An excitatory scorpion toxin. Polypeptide, of 77 amino acids cross-linked by 4 disulfide bridges. Recombinant toxin produced in<br/>Escherichia coli initialy fr...

CAS 32908-73-9 MCD Peptide

MCD Peptide
(CAS: 32908-73-9)

22-amino acid peptide with a strongly basic character and 2 disulfide bridges, , from Apis mellifera bee venom, a blocker of voltage-sensitive K+ channels with ...

CAS 11094-61-4 Erabutoxin A

Erabutoxin A
(CAS: 11094-61-4)

An antagonist of the nicotinic acetylcholine receptor at the neuromuscular junction. Erabutoxin B from Laticauda semifasciata (Sea Snake)

CAS 116235-63-3 Leiurotoxin-1

Leiurotoxin-1
(CAS: 116235-63-3)

Scyllatoxin (Leiurotoxin-1) is a neurotoxin that was originally isolated from Leiurus quinquestriatus hebraeus. Scyllatoxin binds and blocks SK channels (small ...

CAS 110417-88-4 Dolastatin 10

Dolastatin 10
(CAS: 110417-88-4)

Dolastatin 10 is a potent antimitotic peptide from a marine animal, strongly inhibits microtubule assembly.

CAS 57734-70-0 Bicarphen

Bicarphen
(CAS: 57734-70-0)

Diamine oxidase activator. Na+ channels blocker.

CAS 61825-98-7 Imperialine

Imperialine
(CAS: 61825-98-7)

Imperialine is an isosteroidal alkaloid from Fritillaria thunbergii, a short-acting selective M2 muscarinic receptor antagonist.

CAS 56-34-8 Tetraethylammonium chloride

Tetraethylammonium chloride
(CAS: 56-34-8)

Non-selective K+ channel blocker.

Salvipholin
(CAS: 126724-98-9)

Bicyclic diterpenoid of the clerodane series

CAS 5908-99-6 Atropine Sulfate

Atropine Sulfate
(CAS: 5908-99-6)

Atropine is a medication used to treat certain types of nerve agent and pesticide poisonings, some types of slow heart rate, and to decrease saliva production d...

Reference Reading


1. Total synthesis of novel D-ring-modified triptolide analogues: structure–cytotoxic activity relationship studies on the D-ring of triptolide
Bing Zhou, Xiaomei Li, Huanyu Tang, Zehong Miao, Huijin Feng and Yuanchao Li*. Org. Biomol. Chem., 2011, 9, 3176–3179
For a long time, there have been no studies on the structure-activity relationship of the D-ring of triptolide except for two patents, describing some butenolide-modified triptolide analogues without any biological activity data, and our previous paper, reporting that an analogue (compound 6) with a five-membered unsaturated lactam ring has the same activity as the natural triptolide. So the structure-activity relationship of the D-ring is still obscure. To explore whether the five-membered unsaturated lactone ring of triptolide is completely critical to its anticancer activity, compound 3,havinga transposition butenolide, compound 4,which has a furan ring replacing the five-membered unsaturated lactone ring, and compound 5 without the planar D-ring were synthesized for SAR studies of the D-ring. The SAR studies of these tripolide analogues were performed by using ovary (SK-OV-3) and prostate (PC-3) tumor cells.
2. Computational prediction and experimental validation of low-affinity target of triptolide and its analogues
Xiufeng Liu, Kai Wang, Weijuan Zheng,* Jiahuang Li* and Zi-chun Hua*. RSC Adv.,2015, 5,34572–34579
This study was designed to investigate the potential interactions between NRs and triptolide, triptonide and triptriolide. 12 NRs were first screened through docking calculations to identify the putative molecular targets of triptolide. Then themost likely target ERa-LBD was expressed and purified in vitro. The binding capacities between ERa-LBD and three compounds were determined by Surface Plasmon Resonance (SPR) and Isothermal Titration Calorimetry (ITC) analyses. The results were further validated using reporter gene assays. These data revealed ERa act as a previously unknown binding protein of triptolide and triptonide which may provide valuable information for studying the mechanisms and structure–function relationships of these chemicals in vivo.
3. The role of breast cancer resistance protein (Bcrp/Abcg2) in triptolide-induced testis toxicity
Chunzhu Li, Guozhen Xing, Xinming Qi,* Guangji Wang*. Toxicol. Res.,2015, 4,1260–1268
Preclinical studies have revealed that triptolide has strong effects against cancer, collagen-induced arthritis, skin allograft rejection and bone marrow transplantation. Several derivatives of triptolide have entered human clinical trials for cancer and other diseases. However, the clinical uses of triptolide and its derivatives have been limited by their toxicity. Triptolide induced cumulative testis toxicity in some experimental and clinical research studies. The mechanisms of testicular injury induced by triptolide are not characterized well.