Trimeprazine - CAS 84-96-8
Catalog number: 84-96-8
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C18H22N2S
Molecular Weight:
298.45
COA:
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Targets:
Histamine Receptor
Description:
Alimemazine is a phenothiazine derivative as a Histamine Receptor antagonist. It can be used as an antipruritic . It also acts as a sedative, hypnotic, and antiemetic for prevention of motion sickness.
Purity:
98%
Appearance:
Powder
Synonyms:
Alimemazine, Methylpromazine, Alimezine, Repetin, Teralen;N,N,2-trimethyl-3-phenothiazin-10-ylpropan-1-amine;4330-99-8(Tartarte)
Solubility:
Soluble in DMSO
Storage:
-20℃ Freezer
MSDS:
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Application:
antipruritic
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Milligrams-Grams
Density:
1.203 g/cm3
InChIKey:
ZZHLYYDVIOPZBE-UHFFFAOYSA-N
InChI:
1S/C18H22N2S/c1-14(12-19(2)3)13-20-15-8-4-6-10-17(15)21-18-11-7-5-9-16(18)20/h4-11,14H,12-13H2,1-3H3
Canonical SMILES:
CC(CN1c2ccccc2Sc3c1cccc3)CN(C)C
1.A new method for quantitative determination of dimemorfan in human plasma using monolithic silica solid-phase extraction tips.
Hasegawa C1, Kumazawa T, Terada M, Lee XP, Sato K, Uchigasaki S, Kurosaki K. Leg Med (Tokyo). 2012 Sep;14(5):267-71. doi: 10.1016/j.legalmed.2012.03.004. Epub 2012 Apr 28.
Dimemorfan was extracted from human plasma samples (100 μL) using MonoTip C(18) tips, which were packed with a C(18)-bonded monolithic silica gel attached to the inside of the tip. The samples, which contained dimemorfan and trimeprazine as an internal standard (IS), were mixed with 300 μL of distilled water and 50 μL of 1M glycine-sodium hydroxide buffer (pH 10). The mixture was extracted onto the C(18) phase of the tip by 20 sequential aspirating/dispensing cycles using a manual micropipettor. The analytes retained on the C(18) phase were then eluted with methanol by five sequential aspirating/dispensing cycles. The eluate was injected directly into a gas chromatograph and detected by a mass spectrometer with selected ion monitoring in positive electron ionization mode. An Equity-5 fused silica capillary column (30 m × 0.32 mm i.d., film thickness 0.25 μm) gave adequate separation of the dimemorfan, IS, and impurities. The recoveries of dimemorfan and the IS spiked into plasma were ≥83%.
2.Death of an alcohol-dependent patient following intentional drug intoxication: implication of baclofen?
Pape E1, Roman E, Scala-Bertola J, Thivilier C, Javot L, Saint-Marcoux F, Jouzeau JY, Gambier N. Eur Addict Res. 2014;20(6):300-4. doi: 10.1159/000362409. Epub 2014 Oct 4.
Used in the treatment of spasticity at low doses, baclofen is also prescribed off-label at high doses for the treatment of alcohol dependence. Several cases of baclofen intoxication have been reported, but only 1 case deals with the treatment of alcohol dependence. Thus, we report the first death in the context of baclofen off-label use of an alcohol-dependent patient with a high blood baclofen concentration after intentional drug intoxication. The safety profile of baclofen in the treatment of alcohol dependence is reviewed and discussed, underlining the obligatory caution that may support any prescription of high doses of baclofen in this off-label indication and especially in patients with concomitant psychiatric disorders.
3.Case report of atopic dermatitis with refractory pruritus markedly improved with the novel use of clonidine and trimeprazine.
Genois A1, Haig M, Des Roches A, Sirard A, Le May S, McCuaig CC. Pediatr Dermatol. 2014 Jan-Feb;31(1):76-9. doi: 10.1111/j.1525-1470.2012.01756.x. Epub 2012 Jul 2.
We report a 6-year-old boy with severe atopic dermatitis and refractory pruritus. The novel use of clonidine, an adrenergic agonist, along with trimeprazine, led to dramatic improvement. This represents the first case report of clonidine's effect in relieving pruritus in atopic dermatitis.
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CAS 84-96-8 Trimeprazine

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