Trichlormethine - CAS 555-77-1
Catalog number: 555-77-1
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C6H12Cl3N
Molecular Weight:
204.53
COA:
Inquire
Targets:
Others
Description:
Trichloromethane is a solvent, as a powerful blister agent used for chemical warfare.
Purity:
≥98%
Appearance:
Clear Liquid
Synonyms:
Tris-(2-chloroethyl)-amine; 2-chloro-N,N-bis(2-chloroethyl)ethanamine;
Solubility:
Soluble in DMSO
Storage:
Store at -20 °C
MSDS:
Inquire
Application:
Used for chemical warfare.
Quality Standard:
Enterprise Standard
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Grams-Kilos
Boiling Point:
144 °C @15 Torr
Melting Point:
-4 °C
Density:
1.23 g/cm3
InChIKey:
FDAYLTPAFBGXAB-UHFFFAOYSA-N
InChI:
1S/C6H12Cl3N/c7-1-4-10(5-2-8)6-3-9/h1-6H2
Canonical SMILES:
C(CCl)N(CCCl)CCCl
1.Cross-linking of three heavy-chain domains of myosin adenosinetriphosphatase with a trifunctional alkylating reagent.
Hiratsuka T1. Biochemistry. 1988 May 31;27(11):4110-4.
The chemotherapeutic alkylating reagent tris(2-chloroethyl)amine (TCEA) was used as a trifunctional cross-linking reagent with a cross-linking span of 5 A for myosin subfragment 1 (S-1). When S-1 was incubated with TCEA, all three domains of 20, 26, and 50 kDa in the S-1 heavy chain were cross-linked via the highly reactive sulfhydryl group SH1 (Cys-707) on the 20-kDa domain. The cross-linking was accelerated by nucleotides. The present observation is consistent with the proposal that SH1 is close to both the 26- and 50-kDa domains of S-1 and that movement within S-1 associated with the nucleotide binding occurs around SH1 as well as around another reactive thiol, SH2 & Wong, A. G. (1986) Proc. Natl. Acad. Sci. U.S.A. 83, 6392-6396; Hiratsuka, T. (1987) Biochemistry 26, 3168-3173].
2.Ameliorative effect of DRDE 07 and its analogues on the systemic toxicity of sulphur mustard and nitrogen mustard in rabbit.
Kumar P1, Gautam A, Prakash CJ, Kumar A, Ganeshan K, Pathak U, Vijayaraghavan R. Hum Exp Toxicol. 2010 Sep;29(9):747-55. doi: 10.1177/0960327109359641. Epub 2010 Feb 17.
Despite extensive research efforts, there is no unanimous approval of any animal model to evaluate the toxicity of sulphur mustard [SM; bis (2-chloroethyl) sulphide] or nitrogen mustard [HN-3; tris-(2-chloroethyl) amine] and screening of various prophylactic and therapeutic agents against them. In this study, differential toxicity of mustard agents in higher animal model that is male rabbit was determined. Protective efficacy of DRDE 07 [S-2(2-aminoethylamino) ethyl phenyl sulphide] and its analogues were also evaluated against SM and HN-3 toxicity. Differential toxicity study of SM and HN-3 reveals that both the compounds were more toxic by percutaneous route as compared to subcutaneous route. Till date, there is no recommended drug to counteract SM induced toxicity or mortality in vivo. However, DRDE 07 (an amifostine analogue) and its analogues are found to be very effective protective agents against percutaneously exposed SM in rabbits.
3.Quantitation of biomarkers of exposure to nitrogen mustards in urine from rats dosed with nitrogen mustards and from an unexposed human population.
Lemire SW1, Barr JR, Ashley DL, Olson CT, Hayes TL. J Anal Toxicol. 2004 Jul-Aug;28(5):320-6.
The nitrogen mustards bis(2-chloroethyl)ethylamine (HN1), bis(2-chloroethyl)methylamine (HN2), and tris(2-chloroethyl)amine (HN3) have the potential to be used as chemical terrorism agents because of their extreme vesicant properties. We modified a previously reported method to incorporate automated solid-phase extraction, improve chromatography, and include the urinary metabolite for HN3. The improved method was used to measure levels of the urinary metabolites N-ethyldiethanolamine (EDEA), N-methyldiethanolamine (MDEA), and triethanolamine (TEA) in rats dosed with HN1, HN2, and HN3, respectively, and to establish background levels of EDEA, MDEA, and TEA in human urine samples from a population with no known exposure to nitrogen mustards. Rat dosing experiments confirmed that EDEA, MDEA, and TEA could be detected in urine for at least 48 h after exposure to HN1, HN2, and HN3, respectively. Substantial amounts of EDEA (89 ng/mL), MDEA (170 ng/mL), and TEA (1105 ng/mL) were measured in the urine of rats exposed to 10 mg HN1, HN2, and HN3, respectively, 48 h after exposure.
4.Detection of the chemical warfare agents bis-(2-chloroethyl)ethylamine (HN-1) and tris-(2-chloroethyl)amine (HN-3) in air.
Stuff JR1, Cheicante RL, Durst HD, Ruth JL. J Chromatogr A. 1999 Jul 23;849(2):529-40.
This paper describes the method development and validation for detection of the chemical warfare agents HN-1 and HN-3 in air using C8 solid-phase extraction disks followed by liquid desorption and analysis by gas chromatography. The method is contrasted to the standard approach which uses solid sorbent tubes followed by thermal desorption and analysis by gas chromatography.
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CAS 555-77-1 Trichlormethine

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