Triamcinolone Acetonide - CAS 76-25-5
Catalog number: 76-25-5
Category: Inhibitor
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Molecular Formula:
C24H31FO6
Molecular Weight:
434.5
COA:
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Targets:
Glucocorticoid Receptor
Description:
Triamcinolone Acetonide is a long-acting synthetic and a more potent type of triamcinolone, about 8 times as effective as prednisone.
Purity:
>98%
MSDS:
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InChIKey:
YNDXUCZADRHECN-JNQJZLCISA-N
InChI:
InChI=1S/C24H31FO6/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,25)17(28)11-22(16,4)24(19,31-20)18(29)12-26/h7-9,15-17,19,26,28H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1
Canonical SMILES:
CC1(OC2CC3C4CCC5=CC(=O)C=CC5(C4(C(CC3(C2(O1)C(=O)CO)C)O)F)C)C
1.Combined Intravitreal Ranibizumab and Sub-Tenon Injection of Triamcinolone for the Treatment of Diabetic Macular Edema with Retinal Detachment.
Ercalik NY1, Yenerel NM1, Imamoglu S1, Türkseven Kumral E1, Vural ET1. J Ocul Pharmacol Ther. 2016 Apr 19. [Epub ahead of print]
PURPOSE: To evaluate the efficacy of intravitreal ranibizumab (IVR) combined with posterior sub-Tenon injection of triamcinolone acetonide (STTA) for treatment of diabetic macular edema (DME) with serous retinal detachment (SRD).
2.In vitro effects of triamcinolone acetonide and in combination with hyaluronan on canine normal and spontaneous osteoarthritis articular cartilage.
Euppayo T1, Siengdee P1, Buddhachat K1, Pradit W2, Chomdej S3, Ongchai S4, Nganvongpanit K5. In Vitro Cell Dev Biol Anim. 2016 Apr 29. [Epub ahead of print]
The purposes of this study were to examine the cartilage degradation effects of triamcinolone acetonide (TA) on normal and osteoarthritic (OA) primary canine chondrocytes and cartilage explants and to examine the cartilage degradation effects of TA in combination with low-molecular-weight hyaluronan (LMWHA). To assess the effects of these drugs on cell culture, 3,[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay and real-time PCR were used to measure chondrotoxicity and determine gene expression, respectively. Uronic acid and hydroxyproline remaining in cartilage and histopathology were used to estimate the effects of these drugs on cartilage explants. In chondrocyte cultures, TA reduced chondrocyte viability in a concentration-dependent manner. LMWHA 2.5 mg/ml combined with TA at IC20 (0.09 mg/ml) could increase the viability of normal chondrocytes when compared with TA-treated alone. TA at IC20 induced down-regulation of ACAN and induced up-regulation of ADAMTS5 in canine normal chondrocytes.
3.Simultaneous Treatment with Subcutaneous Injection of Golimumab and Intra-articular Injection of Triamcinolone Acetonide (K-Method) in Patients with Rheumatoid Arthritis Undergoing Switching of Biologics: Retrospective Case-Control Study.
Kanbe K1, Chiba J1, Inoue Y1, Taguchi M1, Yabuki A1, Deguchi T1. Clin Med Insights Arthritis Musculoskelet Disord. 2016 Apr 4;9:45-9. doi: 10.4137/CMAMD.S38442. eCollection 2016.
BACKGROUND: Tight control of severe rheumatoid arthritis (RA) in patients with high disease activity, even when using biologics, is sometimes difficult using a treat-to-target strategy. Switching from one biologic to another is associated with lower efficacy than that in treatment-naive cases. We developed the K-method that involves simultaneous treatment with golimumab and intra-articular joint injection of triamcinolone acetonide (TA) in patients undergoing switching of biologics. We performed this retrospective case-control study to investigate the efficacy of achieving an immediate treatment response using the K-method.
4.Presumed Sterile Endophthalmitis After Intravitreal Triamcinolone (Kenalog)-More Common and Less Benign Than We Thought?
Fong AH1, Chan CK. Asia Pac J Ophthalmol (Phila). 2016 Apr 11. [Epub ahead of print]
PURPOSE: This study aimed to review the incidence and clinical outcome of presumed sterile endophthalmitis after the off-label use of intravitreal Kenalog injections (triamcinolone acetonide with 1.5% benzyl alcohol) and to compare it with the presumed sterile endophthalmitis incidence after intravitreal Kenacort-A (0.99% benzyl alcohol) at our center.
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CAS 76-25-5 Triamcinolone Acetonide

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