TP-10 - CAS 898563-00-3
Catalog number: B0084-460312
Category: Inhibitor
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Molecular Formula:
C26H19F3N4O
Molecular Weight:
460.45
COA:
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Targets:
Phosphodiesterase (PDE)
Description:
TP-10 is a PDE10A inhibitor with IC50 of 0.8 nM. It has extremely potent PDE10A inhibitory activity and high selectivity against other PDEs. It is active in the mouse behavioral model for positive symptoms. It demonstrats good in vitro and in vivo activity.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-460312 10 mg $499 In stock
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Purity:
>98%
Appearance:
Solid powder
Synonyms:
TP-10; TP 10; TP10; 2-{4-[4-Pyridin-4-yl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-3-yl]-phenoxymethyl}-quinoline;Substituted pyrazole, 13;2-[[4-[4-pyridin-4-yl-1-(2,2,2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline
Solubility:
10 mM in DMSO
Storage:
-20°C Freezer
MSDS:
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Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Grams to Kilograms
Boiling Point:
564.4±50.0 °C | Condition: Press: 760 Torr
Density:
1.30±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
NOIXNOMHHWGUTG-UHFFFAOYSA-N
InChI:
InChI=1S/C26H19F3N4O/c27-26(28,29)17-33-15-23(18-11-13-30-14-12-18)25(32-33)20-6-9-22(10-7-20)34-16-21-8-5-19-3-1-2-4-24(19)31-21/h1-15H,16-17H2
Canonical SMILES:
C1=CC=C2C(=C1)C=CC(=N2)COC3=CC=C(C=C3)C4=NN(C=C4C5=CC=NC=C5)CC(F)(F)F
1.On substituted pyrazole derivatives. I. 3-Methyl-4-[(Z)-2-(4-methylphenyl)hydrazin-1-ylidene]-1-(3-nitrophenyl)-1H-pyrazol-5(4H)-one and 3-methyl-4-[(Z)-2-(4-methylphenyl)hydrazin-1-ylidene]-1-[4-(trifluoromethyl)phenyl]-1H-pyrazol-5(4H)-one.
Alvarez-Thon L;Bustos C;Molins E;Garland MT;Baggio R Acta Crystallogr C Struct Chem. 2014 Sep;70(Pt 9):837-42. doi: 10.1107/S2053229614017173. Epub 2014 Aug 9.
The title substituted pyrazole derivatives, C17H15N5O3 and C18H15F3N4O, share most of their molecular features, in particular the hydrazinylidene (-HN-N=) rather than the diazene (-N=N-) tautomeric form, and differ only in the substituents (NO2 and CF3) on one of the outer phenyl rings. The molecular units are basically planar, with the rotation of the phenyl rings being hindered by the presence of two intramolecular hydrogen bonds having the keto O atom as acceptor. In both structures, the packing is governed by weak C-H...O, C-H...π and π-π interactions. The subtle way in which minor structural differences lead to rather different supramolecular structures is analysed.
2.Dichlorido(3,5-dimethyl-1H-pyrazole)[(3,5-dimethyl-1H-pyrazol-1-yl)(o-tol-yl)methanone]palladium(II).
Nelana SM;Kruger GJ;Darkwa J Acta Crystallogr Sect E Struct Rep Online. 2007 Dec 18;64(Pt 1):m206-7. doi: 10.1107/S1600536807066627.
In the title compound, [PdCl(2)(C(5)H(8)N(2))(C(12)H(12)N(2)O)], the Pd atom adopts a slightly distorted trans-PdCl(2)N(2) square-planar arrangement. The different Pd-N bond lengths can be related to the the electron-withdrawing effect of the o-toluoyl group on the substituted pyrazole ligand. The complex crystallizes as centrosymmetric hydrogen-bonded dimers through N-H⋯Cl linkages.
3.New pyrazole derivatives containing 1,2,4-triazoles and benzoxazoles as potent antimicrobial and analgesic agents.
Vijesh AM;Isloor AM;Shetty P;Sundershan S;Fun HK Eur J Med Chem. 2013 Apr;62:410-5. doi: 10.1016/j.ejmech.2012.12.057. Epub 2013 Jan 10.
Azole class of compounds are well known for their excellent therapeutic properties. Present paper describes about the synthesis of three series of new 1,2,4-triazole and benzoxazole derivatives containing substituted pyrazole moiety (11a-d, 12a-d and 13a-d). The newly synthesized compounds were characterized by spectral studies and also by C, H, N analyses. All the synthesized compounds were screened for their analgesic activity by the tail flick method. The antimicrobial activity of the new derivatives was also performed by Minimum Inhibitory Concentration (MIC) by the serial dilution method. The results revealed that the compound 11c having 2,5-dichlorothiophene substituent on pyrazole moiety and a triazole ring showed significant analgesic and antimicrobial activity.
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