|Description||Topocecan is a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata.|
|B0084-055461||1 g||$195||In stock|
|Synonyms||SK&F 104864-A; SKF 104864A; SKFS 104864A; NSC 609669; Nogitecan hydrochloride|
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