|Description||Topotecan has been used as a positive control for the identification and analysis of HIF-1α and VEGF inhibitors in human glioma cells under hypoxic conditions. It has also been used for in vitro apoptosis assays in PA317 cells.|
|Synonyms||(S)-10-((dimethylamino)methyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride;Hycamtin; SKF104864;|
Hydrochloride salt of DL-Tetrahydropalmatine is the main active substance of the Chinese herb corydalis which induces hypotension and bradycardia in rats throug...
A non-toxic, complement-activating component of cobra venom Three polypeptide chains with molecular masses of about 70, 50, and 30 kDa, the two large subunits b...
Seco-Duocarmycin DMA is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates.
Bicyclic analog of Ach, a weak muscarinic AChR agonist.
Synthetic, a selective irreversible inhibitor of carboxylesterases
Nitrodienamine, an inhibitor of Ca2+/Mg2+ ATPase.
Noscapine is often used as an antitussive medication.
Derivative of Napelline. Napelline isolated from plant Aconitum karakolicum Diterpenoid Alkaloid Synthesized from Napelline. Napelline is extracted from Aconitu...
Extracted from Haplophyllum perforatum plant (Rutaceae fam.). An antiarrhythmic of first class Quinoline alkaloid
Synthetic, a neuronal nicotinic AChR antagonist.
A selective M-AChR agonist. Rigid bicyclic analog of ACh. Good penetration of biological membranes. Quinuclidine derivative , synthetic.
A scorpion alpha-insect toxin, which prolongs the evoked action potential by an inhibition of sodium current inactivation in insects and mammals.
Irofulven is a semisynthetic sesquiterpene derivative of illudin S, a natural toxin isolated from the fungus Omphalotus illudens. Irofulven alkylates DNA and pr...
Duocarmycin SA is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates.
Seco-Duocarmycin GA is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates.
Monomethyl Auristatin E (MMAE) is a synthetic analog of dolastatin 10 that similarly inhibits tubulin polymerization and exhibits potent cytotoxicity. It is com...
Condelphine was isolated from the roots of Delphinium denudatum. A nicotinic receptor antagonist at the neuromuscular junction and ganglioblocking agent.
Daunorubicin Hcl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM.
α-conotoxin GI (alpha-conotoxin GI) is a conopeptide that has been isolated from the venom of the cone snail Conus geographus. α-conotoxin GI is a competitive a...
Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.