Topiramate - CAS 97240-79-4
Catalog number: 97240-79-4
Category: Inhibitor
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Molecular Formula:
C12H21NO8S
Molecular Weight:
339.36
COA:
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Targets:
mGluR
Description:
Topiramate is a kainate GluR5 receptor antagonist,originally used as an anticonvulsant.
Purity:
>98%
Synonyms:
HSDB-7531; HSDB 7531; HSDB7531; Topiramate; Tipiramato; Topax
MSDS:
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InChIKey:
KJADKKWYZYXHBB-XBWDGYHZSA-N
InChI:
InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1
Canonical SMILES:
CC1(OC2COC3(C(C2O1)OC(O3)(C)C)COS(=O)(=O)N)C
1.Drugs to treat obesity: do they work?
Kim S. Postgrad Med J. 2016 Apr 6. pii: postgradmedj-2015-133388. doi: 10.1136/postgradmedj-2015-133388. [Epub ahead of print]
Obesity is a disease that has historically eluded effective medical therapy. Prior to 2012, phentermine and orlistat were the only medications available to treat obesity in the USA, with phentermine approved only for short-term use. However, as of 2015, the repertoire of pharmacological agents available to treat obesity has greatly expanded to include four new drugs: lorcaserin, phentermine/topiramate extended release (ER), naltrexone ER/wellbutrin ER and liraglutide. Each has a unique mechanism of action and all are intended for long-term use. These newer medications share a common strategy to promote weight loss in that they are designed to manipulate the control of hunger and satiety in the central nervous system. Interestingly, the majority of these new agents are combinations of older medications that have been used for conditions other than obesity. The amount of weight loss seen with these agents beyond placebo varies but generally falls in the range of 3-10% of starting weight and requires continual use of the drug in order for weight loss to be sustained.
2.Influence of caffeine on the protective activity of gabapentin and topiramate in a mouse model of generalized tonic-clonic seizures.
Chrościńska-Krawczyk M1, Jargiełło-Baszak M1, Andres-Mach M2, Łuszczki JJ3, Czuczwar SJ4. Pharmacol Rep. 2016 Mar 26;68(4):680-685. doi: 10.1016/j.pharep.2016.03.011. [Epub ahead of print]
BACKGROUND: Caffeine may interact with classical antiepileptic drugs (AEDs), reducing their anticonvulsant effects in basic seizure models. The aim of the present study was to ascertain whether intraperitoneal caffeine (acute or chronic for 15 days) could attenuate the anticonvulsant effect of some newer AEDs: gabapentin (GBP) and topiramate (TPM) against electroconvulsions in mice.
3.Topiramate-induced severe heatstroke in an adult patient: a case report.
Canel L1, Zisimopoulou S2, Besson M3, Nendaz M4. J Med Case Rep. 2016 Apr 13;10(1):95. doi: 10.1186/s13256-016-0835-5.
BACKGROUND: Heatstroke is a life-threatening condition defined by failure of heat load dissipation, resulting in a core temperature higher than 40 °C (104 °F) associated with neurological dysfunction. Topiramate may cause anhidrosis, potentially resulting in heatstroke, as reported especially in children.
4.Long-term effect of antiepileptic drug switch on serum lipids and C-reactive protein.
Mintzer S1, Miller R2, Shah K2, Chervoneva I3, Nei M2, Skidmore C2, Sperling MR2. Epilepsy Behav. 2016 Apr 9;58:127-132. doi: 10.1016/j.yebeh.2016.02.023. [Epub ahead of print]
BACKGROUND: Prior studies have shown that switching patients from inducing antiepileptic drugs (AEDs) to lamotrigine, levetiracetam, or topiramate reduces serum lipids and C-reactive protein (CRP). These studies were all of short duration, and some drugs, such as zonisamide, have not been investigated.
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CAS 97240-79-4 Topiramate

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