TOFA - CAS 54857-86-2
Catalog number: B0084-374809
Category: Inhibitor
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Molecular Formula:
C19H32O4
Molecular Weight:
324.45
COA:
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Targets:
ACC
Description:
TOFA is a cell-permeable, potent, reversible, and competitive allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA). It inhibits the fatty acid biosynthesis by blocking the synthesis of malonyl-CoA.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-374809 100 mg $358 In stock
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Synonyms:
5-tetradecoxyfuran-2-carboxylic acid; 5-(tetradecyloxy)-2-furancarboxylic acid; 5-(tetradecyloxy)-2-furoic acid; RMI 14514; RMI-14514
Solubility:
Soluble to ≥ 34 mg/mL in DMSO.
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
441.7±25.0 ℃ at 760 mmHg
Melting Point:
117-120 ℃
Density:
1.003±0.06 g/cm3
InChIKey:
CZRCFAOMWRAFIC-UHFFFAOYSA-N
InChI:
InChI=1S/C19H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22-18-15-14-17(23-18)19(20)21/h14-15H,2-13,16H2,1H3,(H,20,21)
Canonical SMILES:
CCCCCCCCCCCCCCOC1=CC=C(O1)C(=O)O
1.Berberine Regulated Lipid Metabolism in the Presence of C75, Compound C, and TOFA in Breast Cancer Cell Line MCF-7.
Tan W1, Zhong Z2, Wang S2, Suo Z1, Yang X1, Hu X1, Wang Y2. Evid Based Complement Alternat Med. 2015;2015:396035. doi: 10.1155/2015/396035. Epub 2015 Aug 13.
Berberine interfering with cancer reprogramming metabolism was confirmed in our previous study. Lipid metabolism and mitochondrial function were also the core parts in reprogramming metabolism. In the presence of some energy-related inhibitors, including C75, compound C, and TOFA, the discrete roles of berberine in lipid metabolism and mitochondrial function were elucidated. An altered lipid metabolism induced by berberine was observed under the inhibition of FASN, AMPK, and ACC in breast cancer cell MCF-7. And the reversion of berberine-induced lipid suppression indicated that ACC inhibition might be involved in that process instead of FASN inhibition. A robust apoptosis induced by berberine even under the inhibition of AMPK and lipid synthesis was also indicated. Finally, mitochondrial function regulation under the inhibition of AMPK and ACC might be in an ACL-independent manner. Undoubtedly, the detailed mechanisms of berberine interfering with lipid metabolism and mitochondrial function combined with energy-related inhibitors need further investigation, including the potential compensatory mechanisms for ATP production and the upregulation of ACL.
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CAS 54857-86-2 TOFA

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