Ticagrelor - CAS 274693-27-5
Catalog number: B0084-089156
Category: Inhibitor
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Molecular Formula:
C23H28F2N6O4S
Molecular Weight:
522.572
COA:
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Targets:
P2Y Receptor
Description:
Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-089156 1 g $169 In stock
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Purity:
>98%
Appearance:
White to Off-White Solid
Synonyms:
AZD-6140; AZD6140; AZD 6140; AR-C 126532XX; AR-C-126532XX; AR-C126532XX; Ticagrelor; brand name: Brilinta; Brilique; Possia
MSDS:
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InChIKey:
OEKWJQXRCDYSHL-FNOIDJSQSA-N
InChI:
InChI=1S/C23H28F2N6O4S/c1-2-7-36-23-27-21(26-15-9-12(15)11-3-4-13(24)14(25)8-11)18-22(28-23)31(30-29-18)16-10-17(35-6-5-32)20(34)19(16)33/h3-4,8,12,15-17,19-20,32-34H,2,5-7,9-10H2,1H3,(H,26,27,28)/t12-,15+,16+,17-,19-,20+/m0/s1
Canonical SMILES:
CCCSC1=NC2=C(C(=N1)NC3CC3C4=CC(=C(C=C4)F)F)N=NN2C5CC(C(C5O)O)OCCO
1.Efficacy and Safety of Ticagrelor as Long-Term Secondary Prevention in Patients with Peripheral Artery Disease and Prior Myocardial Infarction.
Bonaca MP1, Bhatt DL2, Storey RF3, Steg PG4, Cohen M5, Kuder J2, Goodrich E2, Nicolau JC6, Parkhomenko A7, López-Sendón J8, Dellborg M9, Dalby A10, Špinar J11, Aylward P12, Corbalán R13, Abola MT14, Jensen EC15, Held P15, Braunwald E2, Sabatine MS2. J Am Coll Cardiol. 2016 Mar 28. pii: S0735-1097(16)32403-2. doi: 10.1016/j.jacc.2016.03.524. [Epub ahead of print]
BACKGROUND: Peripheral artery disease (PAD) has been associated with heightened ischemic and bleeding risk in patients with prior myocardial infarction (MI).
2.Ticagrelor Attenuates Apoptosis of Lung and Myocardial Cells Induced by Abdominal Aorta Ischemia/Reperfusion.
Findik O1, Kunt AT1, Yazir Y2, Yardimoğlu M2, Yilmaz SG3, Aydin U4, Rençber SF2, Baris O1, Balci C5, Isbir T6. In Vivo. 2016 05-06;30(3):243-249.
AIM: This study aimed to analyze the effect of ticagrelor pretreatment on the prevention of lung and heart injury induced by abdominal aorta ischemia and reperfusion (I/R) and also to determine the effective dose.
3.Pharmacodynamics, pharmacokinetics, and safety of ticagrelor in Chinese patients with stable coronary artery disease.
Li H1, Guo J1, Carlson GF2, Teng R2. Br J Clin Pharmacol. 2016 Apr 1. doi: 10.1111/bcp.12950. [Epub ahead of print]
AIMS: To assess ticagrelor's effects on inhibition of platelet aggregation (IPA), P2Y12 reaction units (PRU; measure of platelet P2Y12 receptor blockade), pharmacokinetic (PK) parameters and safety in Chinese patients with stable coronary artery disease (CAD).
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CAS 274693-27-5 Ticagrelor

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