|Description||ThioLox is an inhibitor of 15-lipoxygenase-1 (15-LOX-1) with both anti-inflammatory and neuroprotective properties (IC50 value of 12 µM). 15-LOX-1 is involved in pro-inflammatory gene expression and central nervous system (CNS) disorders via mediation of oxidative stress and damage of mitochondrial membranes under hypoxic conditions. Ex vivo biological evaluation in precision-cut lung slices (PCLS) showed inhibition of pro-inflammatory gene expression and in vitro studies on neuronal HT-22 cells showed a strong protection against glutamate toxicity for this 15-LOX-1 inhibitor.|
|Brife Description||15-lipoxygenase-1 (15-LOX-1) inhibitor|
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