Tetrahydrouridine - CAS 18771-50-1
Catalog number: 18771-50-1
Molecular Formula:
C9H16N2O6
Molecular Weight:
248.23
COA:
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Description:
Tetrahydrouridine, a derivative of Uridine, is a potent and reversible competitive inhibitor of cytidine deaminase (CDD) (Ki values = 54 and 240 nM for human and E. coli enzymes, respectively). Tetrahydrouridine has the potential to treat tumors with highly expressed CDA as it inhibits cell proliferation through cell cycle regulation despite of cytidine deaminase expression levels deaminase (CDA). Used in combination with cytosine arabinoside (Ara-C) to assess the anti-leukemic activity and anti-tumor activity of Ara-C in in vitro studies.
Purity:
> 95%
Appearance:
Solid powder
Synonyms:
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one; NSC 112907; NSC-112907; NSC112907; Tetrahydrouridine
MSDS:
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Quantity:
Milligrams-Grams
InChIKey:
UCKYOOZPSJFJIZ-XVKVHKPRSA-N
InChI:
1S/C9H16N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h4-8,12-15H,1-3H2,(H,10,16)/t4-,5?,6-,7-,8-/m1/s1
Canonical SMILES:
C1CN(C(=O)NC1O)C2C(C(C(O2)CO)O)O
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