Tetrahydroamentoflavone - CAS 48236-96-0
Catalog number: 48236-96-0
Not Intended for Therapeutic Use. For research use only.
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Tetrahydroamentoflavone isolated from the herbs of Selaginella uncinata. It is a potent XO inhibitor, may be considered as a drug candidate or a chemopreventive agent.
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Yellow powder
(2S)-8-{5-[(2S)-5,7-Dihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl]- 2-hydroxyphenyl}-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H -chromen-4-one
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1.Anti-Escherichia coli activity of extracts from Schinus terebinthifolius fruits and leaves.
da Silva JHS;Simas NK;Alviano CS;Alviano DS;Ventura JA;de Lima EJ;Seabra SH;Kuster RM Nat Prod Res. 2018 Jun;32(11):1365-1368. doi: 10.1080/14786419.2017.1344657. Epub 2017 Jul 3.
Ethanol extracts obtained from Schinus terebinthifolius Raddi fruits and leaves were active against Escherichia coli with MIC of 78 μg mL;-1; for both extracts. Phytochemical analyses revealed a major presence of phenolic acids, tannins, fatty acids and acid triterpenes in the leaves and phenolic acids, fatty acids, acid triterpenes and biflavonoids in the fruits. Major compounds isolated from the plant, such as the acid triterpene schinol, the phenolic acid derivative ethyl gallate and the biflavonoids agathisflavone and tetrahydroamentoflavone, showed very little activity against E. coli. Bioautography of the ethanol extracts on silica gel plate showed inhibition zones for E. coli. They were removed from the plate and the compounds identified as a mixture of myristic, pentadecanoic, palmitic, heptadecanoic, stearic, nonadecanoic, eicosanoic, heneicosanoic and behenic fatty acids.
2.New 3',8''-linked biflavonoids from Selaginella uncinata displaying protective effect against anoxia.
Zheng JX;Zheng Y;Zhi H;Dai Y;Wang NL;Fang YX;Du ZY;Zhang K;Li MM;Wu LY;Fan M Molecules. 2011 Jul 25;16(8):6206-14. doi: 10.3390/molecules16086206.
Seven 3',8''-linked bioflavonoids, including one new compound, (2''S)-2'', 3''-dihydroamentoflavone-4'-methyl ether and six known compounds: (2S)-2,3- dihydroamentoflavone-4'-methyl ether, (2S,2''S)-2,3,2'',3''-tetrahydroamento- flavone-4'-methyl ether, (2S,2''S)-tetrahydroamentoflavone, (2S)-2,3-dihydro- amentoflavone and (2''S)-2'',3''-dihydroamentoflavone (6) and amentoflavone, were isolated from the 60% ethanolic extract of Selaginella uncinata (Desv.) Spring. The structures of these compounds were elucidated mainly by analysis of their 1D and 2D NMR spectroscopic data, and their absolute configurations were determined by circular-dichroism (CD) spectroscopy. All the seven compounds showed protective effect against anoxia in the anoxic PC12 cells assay, in which compound 6 displayed particularly potent activity.
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CAS 48236-96-0 Tetrahydroamentoflavone

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