Tedizolid - CAS 856866-72-3
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
Tedizolid
Catalog Number:
B0084-459901
Synonyms:
TR-700; DA-7157; Torezolid
CAS Number:
856866-72-3
Description:
Torezolid is a novel oxazolidinone for gram-positive infections. It was reversible inhibitors of human MAO-A and MAO-B.
Molecular Weight:
370.34
Molecular Formula:
C17H15FN6O3
COA:
Inquire
MSDS:
Inquire
Targets:
Antibacterial
Catalog Number Size Price Stock Quantity
B0084-459901 1 g $198 In stock
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Chemical Structure
CAS 856866-72-3 Tedizolid

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Reference Reading


1.A highly sensitive and efficient UPLC-MS/MS assay for rapid analysis of tedizolid (a novel oxazolidinone antibiotic) in plasma sample.
Iqbal M1,2. Biomed Chromatogr. 2016 Apr 23. doi: 10.1002/bmc.3749. [Epub ahead of print]
Tedizolid (TDZ) is a novel oxazolidinone class antibiotic, indicated for the treatment of acute bacterial skin and skin structure infections (ABSSSI) in adults. In this study a highly sensitive UPLC-MS/MS assay was developed and validated for the determination of TDZ in rat plasma using rivaroxaban as an internal standard (IS). Both TDZ and IS were separated on Acquity UPLC BEHTM C18 column using isocratic mobile phase comprising of acetonitrile: 20 mM ammonium acetate (85:15, v/v), eluted at 0.3 mL/min flow rate. Plasma sample was processed by liquid liquid extraction technique using ethyl acetate as an extracting agent. The analyte and IS were detected in positive mode using electrospray ionization source. The precursor to product ion transitions at m/z 371.09 > 343.10 for TDZ and m/z 435.97 > 144.94 for IS, were used for the quantification in multiple reaction monitoring mode. The calibration curve was linear in the concentration range of 0.
2.In vitro activity of Tedizolid phosphate against multidrug-resistant Streptococcus pneumoniae isolates from Asian countries.
Baek JY1, Kang CI2, Kim SH3, Ko KS4, Chung DR3, Peck KR5, Hsueh PR6, Thamlikitkul V7, So TM8, Lee NY9, Song JH3; ANSORP Study Group. Diagn Microbiol Infect Dis. 2016 Mar 2. pii: S0732-8893(16)30038-4. doi: 10.1016/j.diagmicrobio.2016.02.022. [Epub ahead of print]
Tedizolid phosphate is a second-generation oxazolidinone prodrug that is potential activity against a wide range of Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus, penicillin-resistant streptococci, and vancomycin-resistant enterococci. The in vitro activity of tedizolid and other comparator agents against multidrug-resistant (MDR) pneumococci from various Asian countries were evaluated. Of the S. pneumoniae clinical pneumonia isolates collected during 2008 and 2009 from 8 Asian countries (Korea, Taiwan, Thailand, Hong Kong, Vietnam, Malaysia, Philippines, and Sri Lanka), 104 isolates of MDR pneumococci were included in this study. Antimicrobial susceptibility testing for 18 antimicrobial agents was performed by broth microdilution method. Tedizolid was highly active against pneumococci. All isolates tested were inhibited at a tedizolid minimum inhibitory concentration (MIC) value of ≤0.25μg/ml (ranged from ≤0.
3.In vitro activity of tedizolid against linezolid-resistant staphylococci and enterococci.
Silva-Del Toro SL1, Greenwood-Quaintance KE1, Patel R2. Diagn Microbiol Infect Dis. 2016 May;85(1):102-4. doi: 10.1016/j.diagmicrobio.2016.02.008. Epub 2016 Feb 9.
The tedizolid MIC of 27 clinical isolates of linezolid-resistant staphylococci and enterococci was determined. Tedizolid MICs were ≥1μg/mL and were 4- to 32-fold lower than those of linezolid. Linezolid resistance mechanisms included G2576T 23S rRNA gene and rplC and rplD mutations.