Tebuconazole - CAS 107534-96-3
Catalog number: 107534-96-3
Category: Inhibitor
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Molecular Formula:
Molecular Weight:
Tebuconazole, a triazole compound, has been found to be an ergosterol biosynthesis inhibitor.
> 95%
White to Off-White Solid
α-[2-(4-Chlorophenyl)ethyl]-α-(1,1-dimethylethyl)-1H-1,2,4-triazole-1-ethanol; (+/-)-Tebuconazole; Ethyltrianol; Etiltrianol
Melting Point:
103-105 °C
1.Triazole fungicide tebuconazole disrupts human placental trophoblast cell functions.
Zhou J1, Zhang J2, Li F3, Liu J4. J Hazard Mater. 2016 May 5;308:294-302. doi: 10.1016/j.jhazmat.2016.01.055. Epub 2016 Jan 27.
Triazole fungicides are one of the top ten classes of current-use pesticides. Although exposure to triazole fungicides is associated with reproductive toxicity in mammals, limited information is available regarding the effects of triazole fungicides on human placental trophoblast function. Tebuconazole (TEB) is a common triazole fungicide that has been extensively used for fungi control. In this work, we showed that TEB could reduce cell viability, disturb normal cell cycle distribution and induce apoptosis of human placental trophoblast cell line HTR-8/SVneo (HTR-8). Bcl-2 protein expression decreased and the level of Bax protein increased after TEB treatment in HTR-8 cells. The results demonstrated that this fungicide induced apoptosis of trophoblast cells via mitochondrial pathway. Importantly, we found that the invasive and migratory capacities of HTR-8 cells decreased significantly after TEB administration. TEB altered the expression of key regulatory genes involved in the modulation of trophoblast functions.
2.Physicologically based toxicokinetic models of tebuconazole and application in human risk assessment.
Jonsdottir SO, Reffstrup TK, Petersen A, Nielsen E. Chem Res Toxicol. 2016 Mar 15. [Epub ahead of print]
A series of physiologically based toxicokinetic (PBTK) models for tebuconazole were developed in four species, rat, rabbit, rhesus monkey and human. The developed models were analysed with respect to the application of the models in higher tier human risk assessment, and the prospect of using such models in risk assessment of cumulative and aggregate exposure is discussed. Relatively simple and biologically sound models were developed using available experimental data as parameters for describing the physiology of the species, as well as the absorption, distribution, metabolism and elimination (ADME) of tebuconazole. The developed models were validated on in vivo half-life data for rabbit with good results, and on plasma and tissue concentration time course data of tebuconazole after iv administration in rabbit. In most cases the predicted concentration levels were seen to be within a factor of two compared to the experimental data, which is the threshold set for the use of PBTK simulation results in risk assessment.
3.Lethal and sub-lethal effects of five pesticides used in rice farming on the earthworm Eisenia fetida.
Rico A1, Sabater C2, Castillo MÁ2. Ecotoxicol Environ Saf. 2016 May;127:222-9. doi: 10.1016/j.ecoenv.2016.02.004. Epub 2016 Feb 10.
The toxicity of five pesticides typically used in rice farming (trichlorfon, dimethoate, carbendazim, tebuconazole and prochloraz) was evaluated on different lethal and sub-lethal endpoints of the earthworm Eisenia fetida. The evaluated endpoints included: avoidance behaviour after an exposure period of 2 days; and mortality, weight loss, enzymatic activities (cholinesterase, lactate dehydrogenase and alkaline phosphatase) and histopathological effects after an exposure period of 14 days. Carbendazim was found to be highly toxic to E. fetida (LC50=2mg/kg d.w.), significantly reducing earthworm weight and showing an avoidance response at soil concentrations that are close to those predicted in rice-fields and in surrounding ecosystems. The insecticide dimethoate showed a moderate acute toxicity (LC50=28mg/kg d.w.), whereas the rest of tested pesticides showed low toxicity potential (LC50 values above 100mg/kg d.w.). For these pesticides, however, weight loss was identified as a sensitive endpoint, with NOEC values approximately 2 times or lower than the calculated LC10 values.
4.Effect of different rates of spent mushroom substrate on the dissipation and bioavailability of cymoxanil and tebuconazole in an agricultural soil.
Álvarez-Martín A1, Sánchez-Martín MJ1, Pose-Juan E1, Rodríguez-Cruz MS2. Sci Total Environ. 2016 Apr 15;550:495-503. doi: 10.1016/j.scitotenv.2016.01.151. Epub 2016 Feb 1.
Physicochemical methods to immobilize pesticides in vulnerable soils are currently being developed to prevent water contamination. Some of these methods include the use of different organic residues to modify soils because they could limit the transport of pesticides and/or facilitate their dissipation. Spent mushroom substrate (SMS) may be used for these purposes. Accordingly a study was conducted under laboratory conditions to know the dissipation and bioavailability of the fungicides cymoxanil and tebuconazole over time in a vineyard soil amended with two rates of spent mushroom substrate (SMS) (5% and 50% (w/w)), selected to prevent the diffuse or point pollution of soil. The dissipation of cymoxanil was more rapid than that of tebuconazole in the different soils studied. The dissipation rate was higher in the amended soil than in the unamended one for both compounds, while no significant differences were observed between the amended soils in either case.
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CAS 107534-96-3 Tebuconazole

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