TCS 1102 - CAS 916141-36-1
Catalog number: 916141-36-1
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C27H26N4O2S
Molecular Weight:
470.59
COA:
Inquire
Targets:
Orexin Receptor (OX Receptor)
Description:
TCS 1102 is a potent, dual orexin receptor antagonist with Ki values of 0.2 and 3 nM for OX2 and OX1 receptors respectively. It is a poor substrate for P-glycoprotein, which demonstrates good brain penetration when administered intraperitoneally. It were found to decrease fear and anxiety in rats 14 days after exposure to footshock. It was also found to have anxiolytic effects that were specific for HR when tested in the elevated T-maze.
Purity:
>98 %
Appearance:
White to off-white Solid
Synonyms:
N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide;2-PyrrolidinecarboxaMide, N-[1,1'-biphenyl]-2-yl-1-[2-[(1-Methyl-1H-benziMidazol-2-yl)thio]acetyl]-, (2S)-;(2S)-N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl]-2-pyrrolidinecarboxamide;TCS 1102, TCS1102, TCS-1102;(2S)-1-[2-(1-methylbenzimidazol-2-yl)sulfanylacetyl]-N-(2-phenylphenyl)pyrrolidine-2-carboxamide
Solubility:
10 mM in DMSO
Storage:
-20°C Freezer
MSDS:
Inquire
Application:
TCS 1102 was found to have anxiolytic effects.
Quality Standard:
In-house standard
Shelf Life:
2 month in rt, long time
Quantity:
Grams to Kilograms
Density:
1.29±0.1 g/cm3 | Condition: Temp: 20 °C Press: 760 Torr
InChIKey:
YSBGRVXJEMSEQY-DEOSSOPVSA-N
InChI:
InChI=1S/C27H26N4O2S/c1-30-23-15-8-7-14-22(23)29-27(30)34-18-25(32)31-17-9-16-24(31)26(33)28-21-13-6-5-12-20(21)19-10-3-2-4-11-19/h2-8,10-15,24H,9,16-18H2,1H3,(H,28,33)/t24-/m0/s1
Canonical SMILES:
CN1C2=CC=CC=C2N=C1SCC(=O)N3CCCC3C(=O)NC4=CC=CC=C4C5=CC=CC=C5
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CAS 916141-36-1 TCS 1102

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