|Description||TC 1 is a high affinity σ1 receptor ligand with selectivity over σ2 receptors (Ki = 10 and 370 nM respectively). TC 1 exhibits low affinity for dopamine (DAT), serotonin (SERT), noradrenalin (NET) transporters (Ki > 10 μM) and dopamine D2 receptors (Ki = 1226 nM).|
|Brife Description||σ1 receptor ligand|
|Purity||≥99% by HPLC|
BD1063 dhydrochloride is a potent and selective antagonist of sigma 1 receptor(Ki= 9.15 nM)with 50-fold more selective over sigma-2(Ki= 449 nM) and >100-fold mo...
4-IBP, an agonist that specially targets sigma receptor (IC50= 1.7 nM), induced marked concentration-dependent decreases in the growth of human cancer cells. σ1...
L-693,403 maleate is the maleate salt of L-693,403, which is a sigma receptor-binding compound. It has excellent selectivity over the dopamine D2 receptor and b...
The hydrochloride salt form of S1RA which is a σ1 receptor antagonist that has been found to have potential effect in pain therapy. It is still under Phase II c...
SM-21 maleate is a potent and selective σ2 antagonist that can increase acetylcholine release at central muscarinic synapses. SM-21 is used as a potent analgesi...
Noscapine is a phthalideisoquinoline alkaloid derived from the opium poppy Papaver somniferum, with mild analgesic, antitussive, and potential antineoplastic ac...
DTG has been found to be a σ-receptor agonist and is useful in studies of its interaction with dopamine drug.
4-PPBP, a piperidine derivative, is a σ ligand and selective non-competitive antagonist at recombinant NR1a/2B NMDA receptors expressed in Xenopus oocytes. It i...
MIN-101, a novel cyclic amide derivative, is a 5-HT2A and sigma 2 receptor antagonist (Ki= 7.53 nM for 5-HT2A and 8.19 nM for sigma-2, respectively).
Rimcazole dihydrochloride is a small molecule antagonist of the σ-1 receptor (IC50 values are 1480 and 386 nM at σ1 and σ2 receptors respectively).
N-[2-(Piperidinylamino)ethyl]-4-iodobenzamide is a selective ligand belongs to benzamides, therapeutic agents for human prostate tumors sigma-1, which binds wit...
NE 100 hydrochloride
NE 100 hydrochloride is a σ1 receptor antagonist with IC50 value of 4.16 nM. It displays antipsychotic activity in vivo.
Siramesine hydrochloride is the hydrochloride salt form of Siramesine. Siramesine is a selective sigma-2 receptor agonist with a potent anticancer activity in v...
BD 1047 dihydrobromide
The dihydrobromide salt form of BD-1047, a selective σ1 receptor antagonist, has been found to have antipsychotic effect and could be probably used against schi...
TC 1 is a high affinity σ1 receptor ligand with selectivity over σ2 receptors (Ki = 10 and 370 nM respectively). TC 1 exhibits low affinity for dopamine (DAT), ...
PRE-084 hydrochloride is a high affinity, selective receptors exhibiting neuroprotective effects. Its IC50 value is 44 nM in the sigma receptor assay. In vitro,...
(±)-PPCC oxalate is a selective sigma (σ) receptor ligand, which is noted to exhibit high affinity for σ1 and also binds at σ2 sites (Ki = 1.5 nM and 50.8 nM re...
Cutamesine, also called as SA4503, is an agonist, small-molecule ligand for the sigma-1 receptor with high selectivity currently in development to mediate neuro...
Siramesine is a selective sigma-2 receptor agonist with a potent anticancer activity in vivo. It was originally devevloped for treating depressant and it has pr...
PRE-084 Hydrochloride is a selective sigma-1 agonist (Ki values are 2.2 and 13091 nM for σ1 and σ2 receptors respectively). PRE-084 is selective for PCP recepto...