Tanshinone IIA - CAS 568-72-9
Catalog number: B0084-188817
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C19H18O3
Molecular Weight:
294.34
COA:
Inquire
Targets:
Amyloid-β | VEGFR
Description:
Tanshinone IIA, under the IUPAC name 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione, one of the original anthracyclines isolated from Salvia miltiorrhiza, inhibits β-amyloid aggregation and protects PC12 cells from β-amyloid-induced apoptosis.
Brife Description:
An Amyloid-β (Aβ) aggregation inhibitor
Appearance:
Orange solid
Synonyms:
Tanshinone IIA; 568-72-9; Tanshinone II; Dan Shen Ketone; Tanshinone B; Tanshinon II; 1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione; C19H18O3; MLS001048863; NSC686519; NSC 686518; SMR000387068; Tanshinone B, Tanshinone II, 568-72-9; 1,6,6-trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dion; 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g]benzofuran-10,11-dione; 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-10,11-dione; Phenanthro(1,2-b)furan-10,11-dione, 6,7,8,9-tetrahydro-1,6,6-trimethyl-;
Tanshinone IIA, Tanshinone B, Tanshinone II; Tanshinone A; tanshinone II A; Phenanthro[1,2-b]furan-10,11-dione, 6,7,8,9-tetrahydro-1,6,6-trimethyl-; Tanshinone 2-A; S2365_Selleck; AC1Q6JLQ; UNII-4GPC9FQG6L; 4GPC9FQG6L; Ambotz568-72-9; AC1L4V8J; BSPBio_001597; BSPBio_002426;
KBioGR_000317; KBioSS_000317; MLS006011834; SPECTRUM1505824; CHEMBL187266; cid_164676; SCHEMBL2026738; BDBM83922; CTK5A5836; KBio2_000317;
KBio2_002885; DTXSID60205352; HYXITZLLTYIPOF-UHFFFAOYSA-N; TR-031585; FT-0652880; N1846; Tanshinone IIA-Supplied by Selleck Chemicals; W-2832; Q-100654; BRD-K00141480-001-03-0; I14-22013; Phenanthro[1,11-dione, 6,7,8,9-tetrahydro-1,6,6-trimethyl-; 1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10,11-dione #; 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g]benzofuran-10,11-quinone; 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[8,7-g]benzofuran-10,11-dione; Tanshinone IIA|6,7,8,9-Tetrahydro-1,6,6-trimethylphenanthro[1,2-b]furan-10,11-dione; 6,6,14-TRIMETHYL-12-OXATETRACYCLO[8.7.0.0(2),?.0(1)(1),(1)?]HEPTADECA-1,7,9,11(15),13-PENTAENE-16,17-DIONE; 6,6,14-trimethyl-12-oxatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1(10),2(7),8,11(15),13-pentaene-16,17-dione; 6,6,14-trimethyl-12-oxatetracyclo[8.7.0.02,7.011,15]heptadeca-1(10),2(7),8,11(15),13-pentaene-16,17-dione;
Solubility:
Soluble to 5 mM in DMSO, and to 5 mM in methanol
Storage:
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -35℃ for long term (months to years).
MSDS:
Inquire
Application:
Anti-Alzheimer agents; Amyloid-β inhibitor; Anti-Infective Agents; Anti-Inflammatory Agents; Immunosuppressive Agents; Anticoagulants; Antineoplastic Agents, Phytogenic;
Boiling Point:
459.031℃ at 760 mmHg
Density:
1.238 g/cm3
InChIKey:
HYXITZLLTYIPOF-UHFFFAOYSA-N
InChI:
1S/C19H18O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,9H,4-5,8H2,1-3H3
Canonical SMILES:
CC1=COC2=C1C(=O)C(=O)C3=C2C=CC4=C3CCCC4(C)C
1.Tanshinone I induces apoptosis and pro-survival autophagy in gastric cancers.
Jing X1, Xu Y2, Cheng W3, Guo S3, Zou Y3, He L4. Cancer Chemother Pharmacol. 2016 Apr 21. [Epub ahead of print]
PURPOSE: To investigate the occurrence of apoptosis and autophagy on human gastric cancer cells after treatment by Tanshinone I, as well as the relationship between them.
2.Tanshinone IIA Induces Heme Oxygenase 1 Expression and Inhibits Cyclic Strain-Induced Interleukin 8 Expression in Vascular Endothelial Cells.
Zhuang S1, Cheng TH2, Shih NL3, Liu JC4, Chen JJ5,6, Hong HJ7, Chan P8,9. Am J Chin Med. 2016 Apr;44(2):377-88. doi: 10.1142/S0192415X1650021X.
Tanshinone IIA is the main effective component of Salvia miltiorrhiza, known as "Danshen," which has been used in many therapeutic remedies in traditional Chinese medicine. However, the direct effects of tanshinone IIA on vascular endothelial cells have not yet been fully described. In the present study, we demonstrated that tanshinone IIA increased heme oxygenase-1 (HO-1) expression in human umbilical vein endothelial cells. Western blot analyses and experiments with specific inhibitors indicated tanshinone IIA enhanced HO-1 expression through the activation of phosphoinositide 3-kinase (PI3K)/Akt and the subsequent induction of nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation. In addition, tanshinone IIA inhibited cyclic strain induced interleukin-8 (IL-8) expression. HO-1 silencing significantly abrogated the repressive effects of tanshinone IIA on strain-induced IL-8 expression, which suggests HO-1 has a role in mediating the effects of tanshinone IIA.
3.Effects of Tanshinone IIA on the modulation of miR‑33a and the SREBP‑2/Pcsk9 signaling pathway in hyperlipidemic rats.
Jia L1, Song N1, Yang G1, Ma Y2, Li X1, Lu R1, Cao H3, Zhang N3, Zhu M2, Wang J1, Leng X1, Cao Y1, Du Y1, Xu Y2. Mol Med Rep. 2016 Apr 14. doi: 10.3892/mmr.2016.5133. [Epub ahead of print]
Tanshinone IIA is the active compound isolated from Salvia miltiorrhiza bunge, which is a traditional Chinese medicine known as Danshen. The aim of the present study was to assess the effect of Tanshinone IIA on the regulation of lipid metabolism in the livers of hyperlipidemic rats and the underlying molecular events. An in vivo model of hyperlipidemia was established in rats, with the animals receiving a daily dose of Tanshinone IIA. The serum lipid profiles were analyzed using an automatic biochemical analyzer, and the histopathological alterations and lipid deposition in liver tissue were assessed using hematoxylin and eosin staining, and oil red O staining, respectively. The mRNA expression levels of microRNA (miR)‑33a, ATP‑binding cassette transporter (ABC)A1, ABCG1, sterol regulatory element‑binding protein 2 (SREBP‑2), proprotein convertase subtilisin/kexin type 9 (Pcsk9) and low‑density lipoprotein receptor (LDL‑R) in liver tissues were measured using reverse transcription‑quantitative polymerase chain reaction, and the protein expression levels of ABCA1, ABCG1, SREBP‑2, Pcsk9, and LDL‑R were analyzed using western blotting.
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CAS 568-72-9 Tanshinone IIA

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