|Description||TAME hydrochloride is a competitive inhibitor of the anaphase-promoting complex/cyclosome (APC/C) and a synthetic substrate for thrombin, trypsin, plasminogen (plasmin), and other proteases. TAME promotes Cdc20 autoubiquitination. TAME was shown to inhibit cyclin proteolysis in mitotic Xenopus oocyte extracts (IC50 = 12 μM) and block cyclin degradation in interphase extract.|
|Brife Description||anaphase-promoting complex/cyclosome (APC/C) inhibitor|
|Purity||≥99% by HPLC|
|Related CAS||901-47-3 (free base)|
|Synonyms||N2-[(4-Methylphenyl)sulfonyl]-L-arginine methyl ester hydrochloride; methyl (2S)-5-(diaminomethylideneamino)-2-[(4-methylphenyl)sulfonylamino]pentanoate hydrochloride|
Apcin is an inhibitor of the E3 ligase activity of the mitotic anaphase-promoting complex/cyclosome (APC/C), which is a large multimeric complex. It functions a...
TAME hydrochloride is a competitive inhibitor of the anaphase-promoting complex/cyclosome (APC/C) and a synthetic substrate for thrombin, trypsin, plasminogen (...
CFM 4 is a CARP-1 mimetic compound that inhibits CARP-1 binding to APC-2. It causes apoptosis and inhibition of cell growth in cancer cells.
TAME is a small molecule anaphase-promoting complex/cyclosome (APC) inhibitor.
MAIT 203 inhibits interaction of APC and Asef (RhoGEF4). It also inhibits colorectal cancer cell migration and invasion in vitro.