Taltobulin - CAS 228266-40-8
Catalog number: 228266-40-8
Category: ADCs
Not Intended for Therapeutic Use. For research use only.
Molecular Formula:
C27H43N3O4
Molecular Weight:
473.32
COA:
Inquire
Tag:
ADCs Cytotoxin
Description:
Taltobulin, also known as HTI-286 and SPA-110, is a fully synthetic analog of the natural tripeptide hemiasterlin, inhibits tubulin polymerization and circumvents transport-based resistance to taxanes. HTI-286 was a potent inhibitor of proliferation (mean IC50 = 2.5 ± 2.1 nm in 18 human tumor cell lines) and had substantially less interaction with multidrug resistance protein (P-glycoprotein) than currently used antimicrotubule agents, including paclitaxel, docetaxel, vinorelbine, or vinblastine.
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Purity:
≥98.0% (HPLC)
Appearance:
White solid powder
Solubility:
Soluble in DMSO, not in water
Storage:
Dry, dark and at 0 - 4 °C for short term (days to weeks) or -20 °C for long term (months to years).
MSDS:
Inquire
Application:
ADCs Cytotoxin
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CAS 228266-40-8 Taltobulin

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