|Description||Taltobulin, also known as HTI-286 and SPA-110, is a fully synthetic analog of the natural tripeptide hemiasterlin, inhibits tubulin polymerization and circumvents transport-based resistance to taxanes. HTI-286 was a potent inhibitor of proliferation (mean IC50 = 2.5 Â± 2.1 nm in 18 human tumor cell lines) and had substantially less interaction with multidrug resistance protein (P-glycoprotein) than currently used antimicrotubule agents, including paclitaxel, docetaxel, vinorelbine, or vinblastine.|
|Appearance||White solid powder|
|Solubility||Soluble in DMSO, not in water|
|Storage||Dry, dark and at 0 - 4 °C for short term (days to weeks) or -20 °C for long term (months to years).|
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