Taltobulin - CAS 228266-40-8
Not Intended for Therapeutic Use. For research use only.
Category:
ADCs
Product Name:
Taltobulin
Catalog Number:
228266-40-8
CAS Number:
228266-40-8
Description:
Taltobulin, also known as HTI-286 and SPA-110, is a fully synthetic analog of the natural tripeptide hemiasterlin, inhibits tubulin polymerization and circumvents transport-based resistance to taxanes. HTI-286 was a potent inhibitor of proliferation (mean IC50 = 2.5 ± 2.1 nm in 18 human tumor cell lines) and had substantially less interaction with multidrug resistance protein (P-glycoprotein) than currently used antimicrotubule agents, including paclitaxel, docetaxel, vinorelbine, or vinblastine.
Molecular Weight:
473.32
Molecular Formula:
C27H43N3O4
COA:
Inquire
MSDS:
Inquire
Tag:
ADCs Cytotoxin
Chemical Structure
CAS 228266-40-8 Taltobulin

Related ADCs Cytotoxin Products


CAS 1953-04-4 Galanthamine hydrobromide

Galanthamine hydrobromide
(CAS: 1953-04-4)

Long-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β-amyloid-...

CAS 134710-25-1 Calciseptine

Calciseptine
(CAS: 134710-25-1)

Calciseptine is a natural neurotoxin isolated from the black mamba Dendroaspis p. polylepis venom. This toxin consists of 60 amino acids with four disulfide bon...

Flodiphoside
(CAS: 142450-99-5)

organophosphoric inhibitor, SA-​152, on the fibrinogen-​coagulating and TAME-​esterase activity of bovine α-​thrombin.

CAS 81720-10-7 Dinophysistoxin-1

Dinophysistoxin-1
(CAS: 81720-10-7)

Potent inhibitor of protein phosphatase tyoe 1 (PP1) and protein phosphatase tyoe 2A (PP2A).

CAS 145808-47-5 Margatoxin

Margatoxin
(CAS: 145808-47-5)

Margatoxin (MgTx) is a component of the venom of Scorpio Centruroides margaritatus. Margatoxin preferentially inhibits voltage-dependent potassium channels Kv1....

Sevedindione

Sevedindione presents an antiarrhythmic activity on arrhythmias caused by Aconitine.

CAS 11033-64-0 N-deacetyllappaconitine

N-deacetyllappaconitine
(CAS: 11033-64-0)

A diterpenoid alkaloids from plants of the Aconitum and Delphinium species, selective blocker of the TTX-sensitive Na+ channel in the heart; potent antiarrhythm...

CAS 7633-69-4 Condelphine

Condelphine
(CAS: 7633-69-4)

Condelphine was isolated from the roots of Delphinium denudatum. A nicotinic receptor antagonist at the neuromuscular junction and ganglioblocking agent.

Benzoylheteratisine hydrochloride
(CAS: 1262758-10-0)

A Na+ channel blocker; potent antiarrhythmic, inhibits voltage-gated Na+ channels in rat brain synaptosomes.

ShK – Stichodactyla toxin
(CAS: 165168-50-3)

ShK (Stichodactyla helianthus Neurotoxin) has been isolated from the venom of the Carribean sea anemone Stoichactis helianthus. ShK inhibits voltage-dependent p...

CAS 32908-73-9 MCD Peptide

MCD Peptide
(CAS: 32908-73-9)

22-amino acid peptide with a strongly basic character and 2 disulfide bridges, , from Apis mellifera bee venom, a blocker of voltage-sensitive K+ channels with ...

CAS 5289-74-7 20-Hydroxyecdysone

20-Hydroxyecdysone
(CAS: 5289-74-7)

20-Hydroxyecdysone (ecdysterone or 20E) is a naturally occurring ecdysteroid hormone which controls the ecdysis (moulting) and metamorphosis of arthropods. It i...

CAS 147794-23-8 Omega-conotoxin MVIIC

Omega-conotoxin MVIIC
(CAS: 147794-23-8)

ω-conotoxin MVIIC (omega conotoxin MVIIC) is a conotoxin that has been isolated from the venom of the cone Conus magus. ω-conotoxin MVIIC is a blocker of P/Q an...

CAS 5008-52-6 Napelline

Napelline
(CAS: 5008-52-6)

Napelline is a diterpenoid alkaloid from plants of the Aconitum,genus, a potent antiarrhythmic with weak hypotensive and N-cholinoblocking effects.

CAS 95506-56-2 Fasciculin 2

Fasciculin 2
(CAS: 95506-56-2)

Potent, reversible acetylcholinesterase inhibitor

CAS 6153-33-9 Diazoline

Diazoline
(CAS: 6153-33-9)

Diazoline is used for symptomatic relief of allergic symptoms caused by histamine release, including nasal allergies and allergic dermatosis.

CAS 12778-32-4 β-Bungarotoxin

β-Bungarotoxin
(CAS: 12778-32-4)

β-Bungarotoxin is a form of bungarotoxin that is fairly common in Krait (Bungaros multicinctus) venoms. A pre-synaptic toxin with enzymatic activity.

CAS 14140-18-2 Trachelanthamine

Trachelanthamine
(CAS: 14140-18-2)

Known as a weak hypotensive, moderate M- and N-cholinolytic pyrrolizidine alkaloid, xtracted from Trachelanthus Korolkowia.

CAS 57817-89-7 Stevioside

Stevioside
(CAS: 57817-89-7)

Diterpenoid , from plants of the Stevia genus, Compositae. Sweetener; reported as possessing anti-hypertensive effects upon hypertensive rats.

CAS 75433-28-2 Laticauda semifasciata III

Laticauda semifasciata III
(CAS: 75433-28-2)

Polypetide, an antagonist of the nicotinic acetylcholine receptor at the neuromuscular junction with a weaker affinity to the receptor than Erabutoxins a and b.