TALIPEXOLE - CAS 101626-70-4
Catalog number: 101626-70-4
Category: Inhibitor
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Molecular Formula:
C10H15N3S
Molecular Weight:
209.31
COA:
Inquire
Targets:
Dopamine Receptor
Description:
Talipexole (B-HT920) is a highly selective agonist of D2 receptor and α2-adrenoceptor which has better ameliorative rate of symptom than bromocriptine and might be effctive in the treatment of Parkinson's disease.
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Purity:
95%
Appearance:
Powder
Synonyms:
TALIPEXOLE;5，6，7，8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4，5-d]azepin-2-amine;Domin;6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine;6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine;Talipexol;Talipexol [spanish];Talipexolum
Solubility:
10 mM in DMSO
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
Talipexole (B-HT920) is a highly selective agonist of D2 receptor and α2-adrenoceptor
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Boiling Point:
364.6ºC at 760mmHg
Density:
1.167g/cm3
InChIKey:
DHSSDEDRBUKTQY-UHFFFAOYSA-N
InChI:
InChI=1S/C10H15N3S/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8/h2H,1,3-7H2,(H2,11,12)
Canonical SMILES:
C=CCN1CCC2=C(CC1)SC(=N2)N
1.The neuroprotective effect of talipexole from paraquat-induced cell death in dopaminergic neuronal cells.
Gómez-Sánchez R1, Bravo-San Pedro JM, Niso-Santano M, Soler G, Fuentes JM, González-Polo RA. Neurotoxicology. 2010 Dec;31(6):701-8. doi: 10.1016/j.neuro.2010.07.005. Epub 2010 Jul 29.
Talipexole is a non-ergot dopamine (DA) agonist that has been used in the treatment of Parkinson's disease. In the present study, we examined the effect of talipexole on paraquat (PQ)-induced N27 cell death and the intracellular pathways involved in this effect. Pretreatment of N27 cells with talipexole (1mM) resulted in significant protection against paraquat-induced cell death. In N27 cells, talipexole inhibited paraquat-induced apoptotic hallmarks such as cytochrome c release, caspase-3 activation, chromatin condensation and externalization of phosphatidilserine. Talipexole pretreatment prevents the reduction in the anti-apoptotic Bcl-x(L) protein and increases in the pro-apoptotic form of Bak and p-Bad, both induced by PQ. Finally, we also observed that talipexole abrogates the activation of cell death pathways JNK1/2 and p38 produced by PQ, and increases the phosphorylated (active) forms of the pro-survival pathways ERK1/2 and Akt. These results reveal that talipexole exerts a neuroprotective effect in a mesencephalic cell line exposed to the neurotoxin PQ, which is related to the etiology of Parkinson's disease.
2.Pharmacokinetic profile of talipexole in healthy volunteers is not altered when it is co-administered with Madopar (co-beneldopa).
Zhang TT1, Song M, Hang TJ, Xu XF, Wen AD, Yang L, Jia L. J Clin Pharm Ther. 2009 Jun;34(3):345-54. doi: 10.1111/j.1365-2710.2008.01008.x.
OBJECTIVES: To investigate the pharmacokinetics of talipexole hydrochloride tablets and the potential influence of Madopar (benserazide and levodopa combination; co-beneldopa) tablets on talipexole's pharmacokinetics when the two tablets are co-administered orally to healthy Chinese volunteers.
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Chemical Structure

CAS 101626-70-4 TALIPEXOLE

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