TALIPEXOLE - CAS 101626-70-4
Catalog number: 101626-70-4
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C10H15N3S
Molecular Weight:
209.31
COA:
Inquire
Targets:
Dopamine Receptor
Description:
Talipexole (B-HT920) is a highly selective agonist of D2 receptor and α2-adrenoceptor which has better ameliorative rate of symptom than bromocriptine and might be effctive in the treatment of Parkinson's disease.
Purity:
95%
Appearance:
Powder
Synonyms:
TALIPEXOLE;5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepin-2-amine;Domin;6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine;6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine;Talipexol;Talipexol [spanish];Talipexolum
Solubility:
10 mM in DMSO
Storage:
-20ºC Freeze
MSDS:
Inquire
Application:
Talipexole (B-HT920) is a highly selective agonist of D2 receptor and α2-adrenoceptor
Shelf Life:
As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Quantity:
Milligrams-Grams
Boiling Point:
364.6ºC at 760mmHg
Density:
1.167g/cm3
InChIKey:
DHSSDEDRBUKTQY-UHFFFAOYSA-N
InChI:
InChI=1S/C10H15N3S/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8/h2H,1,3-7H2,(H2,11,12)
Canonical SMILES:
C=CCN1CCC2=C(CC1)SC(=N2)N
1.The neuroprotective effect of talipexole from paraquat-induced cell death in dopaminergic neuronal cells.
Gómez-Sánchez R1, Bravo-San Pedro JM, Niso-Santano M, Soler G, Fuentes JM, González-Polo RA. Neurotoxicology. 2010 Dec;31(6):701-8. doi: 10.1016/j.neuro.2010.07.005. Epub 2010 Jul 29.
Talipexole is a non-ergot dopamine (DA) agonist that has been used in the treatment of Parkinson's disease. In the present study, we examined the effect of talipexole on paraquat (PQ)-induced N27 cell death and the intracellular pathways involved in this effect. Pretreatment of N27 cells with talipexole (1mM) resulted in significant protection against paraquat-induced cell death. In N27 cells, talipexole inhibited paraquat-induced apoptotic hallmarks such as cytochrome c release, caspase-3 activation, chromatin condensation and externalization of phosphatidilserine. Talipexole pretreatment prevents the reduction in the anti-apoptotic Bcl-x(L) protein and increases in the pro-apoptotic form of Bak and p-Bad, both induced by PQ. Finally, we also observed that talipexole abrogates the activation of cell death pathways JNK1/2 and p38 produced by PQ, and increases the phosphorylated (active) forms of the pro-survival pathways ERK1/2 and Akt. These results reveal that talipexole exerts a neuroprotective effect in a mesencephalic cell line exposed to the neurotoxin PQ, which is related to the etiology of Parkinson's disease.
2.Pharmacokinetic profile of talipexole in healthy volunteers is not altered when it is co-administered with Madopar (co-beneldopa).
Zhang TT1, Song M, Hang TJ, Xu XF, Wen AD, Yang L, Jia L. J Clin Pharm Ther. 2009 Jun;34(3):345-54. doi: 10.1111/j.1365-2710.2008.01008.x.
OBJECTIVES: To investigate the pharmacokinetics of talipexole hydrochloride tablets and the potential influence of Madopar (benserazide and levodopa combination; co-beneldopa) tablets on talipexole's pharmacokinetics when the two tablets are co-administered orally to healthy Chinese volunteers.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Dopamine Receptor Products


CAS 67383-44-2 RU 24213

RU 24213
(CAS: 67383-44-2)

RU 24213 is a dopamine D2 receptor agonist as well as a kappa opioid receptor antagonist.

CAS 170857-36-0 Sonepiprazole hydrochloride

Sonepiprazole hydrochloride
(CAS: 170857-36-0)

Sonepiprazole hydrochloride is a selective dopamine D4 antagonist and displays low affinity for other dopamine receptors, and noradrenalin, serotonin and histam...

CAS 71787-83-2 5-Hydroxy-DPAT hydrobromide

5-Hydroxy-DPAT hydrobromide
(CAS: 71787-83-2)

A potent and selective dopamine (DA) D2 receptor agonist developed as a PET agent.

CAS 1246094-81-4 (R)-6-Hydroxy-DPAT hydrobromide

(R)-6-Hydroxy-DPAT hydrobromide
(CAS: 1246094-81-4)

A dopamine receptor agonist.

CAS 1257326-23-0 NPEC-caged-dopamine

NPEC-caged-dopamine
(CAS: 1257326-23-0)

NPEC-caged-dopamine is a caged version of dopamine. It can release dopamine leading to dopamine D1 receptor activation upon UV light illumination.

CAS 440-17-5 Trifluoperazine Hydrochloride

Trifluoperazine Hydrochloride
(CAS: 440-17-5)

Trifluoperazine is a dopamine D2 receptor inhibitor with IC50 of 1.1 nM.

CAS 1257326-24-1 GSK 789472 hydrochloride

GSK 789472 hydrochloride
(CAS: 1257326-24-1)

GSK 789472 hydrochloride is a selective dopamine D3 receptor antagonist and D2 partial agonist (pEC50 values are <5.5 and 8.3, respectively). GSK 789472 exhibit...

CAS 93601-85-5 (R)-5-Methoxy-N-propyl-2-aminotetraline hydrochloride

(R)-5-Methoxy-N-propyl-2-aminotetraline
(CAS: 93601-85-5)

(R)-5-Methoxy-N-propyl-2-Aminotetraline hydrochloride is a dopamine receptor agonist and an intermediate in the production of antipsychotic agents and antiparki...

Chemical Structure

CAS 101626-70-4 TALIPEXOLE

Quick Inquiry

Verification code

Featured Items