An Overview of c-FMS
Colony stimulating factor 1 (CSF-1) is also called macrophage colony stimulating factor (M-CSF). Its receptor (CSF-1R or c-FMS), encoded by oncogene cfms, is expressed in monocytes, precursors of macrophages and bone marrow cells, fetal membrane trophoblast and chorioma cells. The transcription of its mRNA is controlled by two independent promoters, which are regulated by the transcription factor PU1. CCAAT enhancer binding protein (C/EBP) and transcription factor AML1 (CBFa2) can co-activate the promoter of CSF1R.Human CSF1R is a transmembrane glycoprotein consisting of 972 amino acid residues with a molecular weight of 150ku.
The Kinase of c-FMS
The kinase target protein of CSF-1R is a protein containing tyrosine and serine / threonine, one of which is called p120cbl, which interacts with functional proteins through src homologous region 2 (SH2) of Grb2 and mediating protein Nck.P120cbl can be phosphorylated not only by CSF-1R, but also by Fe receptor (FcYR) and kit of epidermal growth factor receptor (EGFR).P120cbl is also the substrate of tyrosine kinase activated by T cell antigen receptor, and it can be negatively regulated by the product of cbl homologous sli-1 of Abl tyrosine kinase. Early studies have shown that CSF-1 R can phosphorylate p56 rapidly in Bewo cell line. In fact, the activation of almost all proteins in CSF-1R-mediated signal transduction is related to the kinase pathway, and p120cbl plays a central role in the CSF-1R-mediated kinase pathway.
c-FMS and diseases
Although the function of CSF-1R is limited to cell proliferation and differentiation, it plays an important role in the normal metabolism of cells. The relationship between CSF-1R and apoptosis is also worth studying. The membrane binding form of CSF-1 (mCSF1) is highly expressed in malignant tumor cells such as myeloid leukemia, Hodgkin's disease and liver cancer, which can act continuously with CSF1R and eventually lead to uncontrolled cell growth and differentiation and carcinogenesis. Thus,elucidating the mechanism of this action will be helpful to reveal the mechanism of carcinogenesis and metastasis. It is feasible to treat some diseases by blocking excessive signal transduction.
 Cui Jun, Yang Donghua. CSF-1 receptor r.c-fms and hepatocellular carcinoma [J]. World Chinese Digest Magazine 2000 (06): 696-697.