|Description||Sumanirole maleate, also referred as PNU 95666E or U95666E, is a high affinity D2 receptor full agonist that shows >200-fold selectivity over dopamine receptor subtypes (Ki values are 9.0, 1940, >2190 and >7140 for D2, D3, D4 and D1 receptors respectively)
with an ED50 of about 46 nM.
IC50 value: 46 nM (EC50)
Target: D2 receptor
Sumanirole was developed for the treatment of Parkinson's disease and restless leg syndrome. While it has never been approved for medical use. Sumanirole is a highly valuable tool compound for basic research to identify neurobiological mechanisms that are based on a dopamine D2-linked (vs. D1, D3, D4, and D5-linked) mechanism of action.
|Brife Description||A highly selective D2 receptor full agonist|
|Synonyms||5,6-dihydro-5-(methylamino)-4H-imidazo(4,5,1ij)-quinolin-2(1H)-one (Z)-2-butenedioate; PNU-95666; PNU95666; PNU 95666; Sumanirole; U 95666E; U-95666E; U95666E|
|Solubility||10 mM in DMSO|
|Storage||Store in a cool and dry place (or refer to the Certificate of Analysis).|
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