Sulfameter - CAS 651-06-9
Catalog number: 651-06-9
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C11H12N4O3S
Molecular Weight:
280.3
COA:
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Targets:
Antibacterial
Description:
Sulfameter is a long-acting sulfonamide antibacterial. It is used as a leprostatic agent and in the treatment of urinary tract infections.
Purity:
>98%
Synonyms:
SG-75; SG 75; SG75; I-2586; I 2586; I2586; NSC 683528; NSC-683528; NSC683528;
MSDS:
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InChIKey:
GPTONYMQFTZPKC-UHFFFAOYSA-N
InChI:
InChI=1S/C11H12N4O3S/c1-18-9-6-13-11(14-7-9)15-19(16,17)10-4-2-8(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)
Canonical SMILES:
COC1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N
1.Chemiluminescence enzyme immunoassay for the determination of sulfamethoxydiazine.
Wu Y1, Yu S, Yu F, Yan N, Qu L, Zhang H. Spectrochim Acta A Mol Biomol Spectrosc. 2011 Oct 15;81(1):544-7. doi: 10.1016/j.saa.2011.06.047. Epub 2011 Jul 6.
Sulfamethoxydiazine (SMD), which is often used for animal disease treatment, is harmful to human health. No SMD residue should be detected in food in some countries, such as USA and Japan. Therefore, it is significant to develop a high-throughput, high-sensitivity and accurate method for the determination of the content of SMD in food. In this paper, chemiluminescence enzyme immunoassay (CLEIA) was developed for quantification of SMD. For this method, the limit of detection was 3.2 pg/ml, the linear range was from 10 to 2000 pg/ml, the within-day and inter-day precision were below 13% and below 18%, respectively, and the recovery was from 85% to 105%. Milk and egg were selected as samples to be examined with this method, and the result indicated that this CLEIA method was suitable for screening and quality control of food.
2.[Occurrence of quinolone and sulfonamide antibiotics in swine and cattle manures from large-scale feeding operations of Guangdong Province].
Tai YP1, Luo XD, Mo CH, Li YW, Wu XL, Liu XY. Huan Jing Ke Xue. 2011 Apr;32(4):1188-93.
The occurrence and distribution of four quinolones and four sulfonamides in swine and cattle feces sampled from twenty large-scale feeding operations in different areas of Guangdong province were detected using solid phase extraction (SPE) and high performance liquid chromatography (HPLC). Quinolone and sulfonamide compounds were observed in all pig dung samples. Their total concentrations ranged from 24.5 microg/kg to 1516.2 microg/kg (F. W.) with an average of 581.0 microg/kg and ranged from 1925.9-13399.5 microg/kg with an average of 4403.9 microg/kg respectively. The dominant compounds in pig feces were ciprofloxacin and enrofloxacin for quinolones and sulfamerazine and sulfamethoxazole for sulfonamides. Quinolone compounds which dominated with norfloxacin and ciprofloxacin were also observed in all cattle dung samples, its total concentrations ranged from 73.2 microg/kg to 1328.0 microg/kg which averaged 572.9 microg/kg. While the positive rates of sulfonamide compounds detected in cattle dung samples were above 90%, predominated by sulfamethoxazole and sulfamerazine.
3.Identification of isobaric amino-sulfonamides without prior separation.
Barry SJ1, Wolff JC. Rapid Commun Mass Spectrom. 2012 Feb 29;26(4):419-29. doi: 10.1002/rcm.6118.
RATIONALE: Direct analysis mass spectrometry (DAMS) techniques offer increased speed of analysis without the need for sample preparation or prior separation. A feature of these techniques is that all ionisable species will typically be analysed at the same time which makes the ability to distinguish between isobaric compounds increasingly important.
4.Sulfonamides identified as plant immune-priming compounds in high-throughput chemical screening increase disease resistance in Arabidopsis thaliana.
Noutoshi Y1, Ikeda M, Saito T, Osada H, Shirasu K. Front Plant Sci. 2012 Oct 31;3:245. doi: 10.3389/fpls.2012.00245. eCollection 2012.
Plant activators are agrochemicals that protect crops from diseases by activating the plant immune system. To isolate lead compounds for use as practical plant activators, we screened two different chemical libraries composed of various bioactive substances by using an established screening procedure that can selectively identify immune-priming compounds. We identified and characterized a group of sulfonamide compounds - sulfameter, sulfamethoxypyridazine, sulfabenzamide, and sulfachloropyridazine - among the various isolated candidate molecules. These sulfonamide compounds enhanced the avirulent Pseudomonas-induced cell death of Arabidopsis suspension cell cultures and increased disease resistance in Arabidopsis plants against both avirulent and virulent strains of the bacterium. These compounds did not prevent the growth of pathogenic bacteria in minimal liquid media at 200 μM. They also did not induce the expression of defense-related genes in Arabidopsis seedlings, at least not at 24 and 48 h after treatment, suggesting that they do not act as salicylic acid analogs.
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CAS 651-06-9 Sulfameter

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