STK16-IN-1 - CAS 1223001-53-3
Catalog number: B0084-007329
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
Molecular Weight:
STK16-IN-1, a pyrrolonaphthyridinone compound, only potently inhibited STK16 (relative activity remaining 0.65%) and mTOR (relative activity remaining 0.4%) at a concentration of 10 μM.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-007329 300 mg $599 In stock
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Brife Description:
A STK16 kinase inhibitor (IC50= 295 nM)
STK16-IN-1; STK16 IN 1; STK16IN1; JWC-029; JWC 029; JWC029; 1-(4-fluoro-3-methylphenyl)-7H-pyrrolo[2,3-h][1,6]naphthyridin-2-one
DMSO: 15 mg/mL
Store in a cool and dry place (or refer to the Certificate of Analysis).
Boiling Point:
582.3±50.0 ℃ at 760 Torr
1.38±0.1 g/cm3
Canonical SMILES:
1.Discovery of a Highly Selective STK16 Kinase Inhibitor.
Liu F;Wang J;Yang X;Li B;Wu H;Qi S;Chen C;Liu X;Yu K;Wang W;Zhao Z;Wang A;Chen Y;Wang L;Gray NS;Liu J;Zhang X;Liu Q ACS Chem Biol. 2016 Jun 17;11(6):1537-43. doi: 10.1021/acschembio.6b00250. Epub 2016 Apr 22.
STK16, a serine/threonine protein kinase, is ubiquitously expressed and is conserved among all eukaryotes. STK16 has been implicated to function in a variety of cellular processes such as VEGF and cargo secretion, but the pathways through which these effects are mediated remain to be elucidated. Through screening of our focused library of kinase inhibitors, we discovered a highly selective ATP competitive inhibitor, STK16-IN-1, which exhibits potent inhibitory activity against STK16 kinase (IC50: 0.295 μM) with excellent selectivity across the kinome as assessed using the KinomeScan profiling assay (S score (1) = 0.0). In MCF-7 cells, treatment with STK16-IN-1 results in a reduction in cell number and accumulation of binucleated cells, which can be recapitulated by RNAi knockdown of STK16. Co-treatment of STK16-IN-1 with chemotherapeutics such as cisplatin, doxorubicin, colchicine, and paclitaxel results in a slight potentiation of the antiproliferative effects of the chemotherapeutics. STK16-IN-1 provides a useful tool compound for further elucidating the biological functions of STK16.
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CAS 1223001-53-3 STK16-IN-1

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