STK16-IN-1 - CAS 1223001-53-3
Catalog number: B0084-007329
Category: Inhibitor
Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Molecular Formula:
C17H12FN3O
Molecular Weight:
293.3
COA:
Inquire
Targets:
Others
Description:
STK16-IN-1, a pyrrolonaphthyridinone compound, only potently inhibited STK16 (relative activity remaining 0.65%) and mTOR (relative activity remaining 0.4%) at a concentration of 10 μM.
Ordering Information
Catalog Number Size Price Stock Quantity
B0084-007329 300 mg $599 In stock
Bulk Inquiry
Brife Description:
A STK16 kinase inhibitor (IC50= 295 nM)
Synonyms:
STK16-IN-1; STK16 IN 1; STK16IN1; JWC-029; JWC 029; JWC029; 1-(4-fluoro-3-methylphenyl)-7H-pyrrolo[2,3-h][1,6]naphthyridin-2-one
Solubility:
DMSO: 15 mg/mL
Storage:
Store in a cool and dry place (or refer to the Certificate of Analysis).
MSDS:
Inquire
Boiling Point:
582.3±50.0 ℃ at 760 Torr
Density:
1.38±0.1 g/cm3
InChIKey:
WQNRDXHKVSKUPI-UHFFFAOYSA-N
InChI:
1S/C17H12FN3O/c1-10-8-12(3-4-14(10)18)21-15(22)5-2-11-9-20-17-13(16(11)21)6-7-19-17/h2-9H,1H3,(H,19,20)
Canonical SMILES:
CC1=C(C=CC(=C1)N2C(=O)C=CC3=CN=C4C(=C32)C=CN4)F
1.Discovery of a Highly Selective STK16 Kinase Inhibitor.
Liu F;Wang J;Yang X;Li B;Wu H;Qi S;Chen C;Liu X;Yu K;Wang W;Zhao Z;Wang A;Chen Y;Wang L;Gray NS;Liu J;Zhang X;Liu Q ACS Chem Biol. 2016 Jun 17;11(6):1537-43. doi: 10.1021/acschembio.6b00250. Epub 2016 Apr 22.
STK16, a serine/threonine protein kinase, is ubiquitously expressed and is conserved among all eukaryotes. STK16 has been implicated to function in a variety of cellular processes such as VEGF and cargo secretion, but the pathways through which these effects are mediated remain to be elucidated. Through screening of our focused library of kinase inhibitors, we discovered a highly selective ATP competitive inhibitor, STK16-IN-1, which exhibits potent inhibitory activity against STK16 kinase (IC50: 0.295 μM) with excellent selectivity across the kinome as assessed using the KinomeScan profiling assay (S score (1) = 0.0). In MCF-7 cells, treatment with STK16-IN-1 results in a reduction in cell number and accumulation of binucleated cells, which can be recapitulated by RNAi knockdown of STK16. Co-treatment of STK16-IN-1 with chemotherapeutics such as cisplatin, doxorubicin, colchicine, and paclitaxel results in a slight potentiation of the antiproliferative effects of the chemotherapeutics. STK16-IN-1 provides a useful tool compound for further elucidating the biological functions of STK16.
Molecular Weight Calculator Molarity Calculator Solution Dilution Calculator

Related Products


CAS 2646-71-1 NADPH tetrasodium salt

NADPH tetrasodium salt
(CAS: 2646-71-1)

NADPH tetrasodium salt is an ubiquitous coenzyme that acts as an electron donor in various biological reactions.<br/>Nutritional supplement in health care produ...

CAS 849214-04-6 3'3'-cGAMP

3'3'-cGAMP
(CAS: 849214-04-6)

STING agonist

CAS 83-63-6 Diacetazotol

Diacetazotol
(CAS: 83-63-6)

Diacetazotol, also referred to Pellidol, inhibits dioxin-induced ethoxyresorufin-O-deethylase (EROD) activity (IC50= 75±4 nM) and has been used in ointment or d...

CAS 2032-65-7 Methiocarb

Methiocarb
(CAS: 2032-65-7)

Methiocarb, also called as Mercaptodimethur, is a carbamate pesticide used in agriculture as insecticides and herbicides.

CAS 1345407-05-7 LTX-315

LTX-315
(CAS: 1345407-05-7)

LTX-315, an oncolytic peptide with potent anticancer activity, kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization. LTX-315 inh...

CAS 1188296-52-7 PF 4800567

PF 4800567
(CAS: 1188296-52-7)

PF 4800567 is a potent and selective casein kinase 1ε (Csnk1e or CK-1ε) inhibitor (IC50 = 32 nM).

CVT-3369
(CAS: 172430-48-7)

CVT-3369, a piperazineacetic acid derivative, is probably effective in some of biological studies.

PXS-5446

PXS-5446 is a lysyl oxidase inhibitor. Study in GATA-1low mice reveals that PXS-5446 decreases fibrosis in bone marrow and spleen size. PXS-5446 is promisingly ...

Chemical Structure

CAS 1223001-53-3 STK16-IN-1

Quick Inquiry

Verification code

Featured Items