SSR 146977 hydrochloride - CAS 264618-38-4
Category: Inhibitor
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Molecular Formula:
C35H42Cl2N4O2.HCl
Molecular Weight:
658.11
COA:
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Targets:
Neurokinin Receptor
Description:
SSR 146977 hydrochloride is a potent and selective NK3 receptor antagonist (Ki = 0.26 and 19.3 nM in CHO cells expressing the human NK3 and NK2 receptor, respectively). SSR 146977 also exhibits an inhibitory effect on senktide-induced inositol monophosphate formation and intracellular calcium mobilization (IC50 = 10 nM).
Brife Description:
NK3 receptor antagonist
Purity:
≥98% by HPLC
Synonyms:
SSR 146977 hydrochloride; SSR146977 hydrochloride; SSR-146977 hydrochloride; N1-[1-3-[(3R)-1-Benzoyl-3-(3-(3,4-dichlorophenyl)-3-piperidinyl]propyl]-4-phenyl-piperidinyl]-N,N-dimethylurea hydrochloride
MSDS:
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InChIKey:
HYPKKQPFHSNZBY-GXUZKUJRSA-N
InChI:
InChI=1S/C35H42Cl2N4O2.ClH/c1-39(2)33(43)38-35(28-13-7-4-8-14-28)19-23-40(24-20-35)21-9-17-34(29-15-16-30(36)31(37)25-29)18-10-22-41(26-34)32(42)27-11-5-3-6-12-27;/h3-8,11-16,25H,9-10,17-24,26H2,1-2H3,(H,38,43);1H/t34-;/m0./s1
Canonical SMILES:
CN(C)C(=O)NC1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5.Cl
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CAS 264618-38-4 SSR 146977 hydrochloride

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