|Targets||Corticotropin-releasing factor (CRF)|
|Description||SSR 125543A is a potent and orally bioactive corticotropin-releasing factor 1 receptor (CRF1) antagonist (pKi values of 8.73 and 9.08 for human cloned or native CRF1 receptors, respectively) with 1000-fold selectivity for CRF1 over CRF2α receptor and CRF binding protein. SSR 125543A exhibited antidepressant and anxiolytic properties in the Flinders Sensitive Line rats.|
|Brife Description||CRF1 antagonist|
|Synonyms||SR-125543A; SR125543A; LS-150601; LS150601; LS 150601; 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thiazol-2-amine hydrochloride|
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α-helical CRF 9-41
α-helical CRF 9-41 has been found to be a corticotropin-releasing factor receptor antagonist.
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SSR 125543A is a potent and orally bioactive corticotropin-releasing factor 1 receptor (CRF1) antagonist (pKi values of 8.73 and 9.08 for human cloned or native...