α-Spinasterol - CAS 481-18-5
Catalog number: 481-18-5
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Molecular Formula:
C29H48O
Molecular Weight:
412.7
COA:
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Chemical Family:
Other Natural Compounds
Description:
Alpha-Spinasterol, a natural steroid found in the roots of Bupleurum chinense DC, exhibits the activity of anti-inflammatory and antinociceptive effects against acetic acid-induced visceral pain. As a TRPV1 receptor antagonist, alpha-Spinasterol elevates the seizure threshold in three acute seizure tests in mice.
Purity:
>97%
Appearance:
Powder
Synonyms:
(3β,5α,22E)-Stigmasta-7,22-dien-3-ol; α-Spinasterin; Bessisterol
MSDS:
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Application:
anti-inflammatory; anti-nociceptive
Quality Standard:
Enterprise Standard
Quantity:
Milligrams-Grams
Density:
0.98g/cm3
1.In vitro Activities of Pfaffia glomerata Root Extract, Its Hydrolyzed Fractions and Pfaffic Acid Against Trypanosoma cruzi Trypomastigotes.
Silva ML;Pereira AC;Ferreira DS;Esperandim VR;Símaro GV;Lima TC;Januário AH;Pauletti PM;Rehder VL;Crevelin EJ;Cunha WR;Crotti AE;Bastos JK Chem Biodivers. 2017 Jan;14(1). doi: 10.1002/cbdv.201600175. Epub 2017 Jan 3.
This article reports on the in vitro activity of the hydroalcoholic extract of Pfaffia glomerata roots, its hydrolyzed fractions, and pfaffic acid against Trypanosoma cruzi. The hydroalcoholic extract obtained from dried, milled P. glomerata roots was submitted to acid hydrolysis followed by partition with CHCl;3; . The concentrated CHCl;3; fraction was suspended in MeOH/H;2; O and partitioned with hexane (F1), CHCl;3; (F2), and AcOEt (F3), in this sequence. The trypanocidal activity of the hydrolyzed extract and its fractions was evaluated in vitro. The hydroalcoholic extract displayed low activity, but fraction F1 was active against trypomastigotes of the Y strain of T. cruzi, with IC;50; = 47.89 μg/ml. The steroids campesterol (7.7%), stigmasterol (18.7%), β-sitosterol (16.8%), Δ;7; -stigmastenol (4.6%), and Δ;7; -spinasterol (7.5%) were the major constituents of F1, along with fatty acid esters (7.6%) and eight aliphatic hydrocarbons (30.1%). Fractions F2 and F3 exhibited moderate activity, and pfaffic acid, one of the main chemical constituents of these fractions, displayed IC;50; = 44.78 μm (21.06 μg/ml). On the other hand, the hydroalcoholic extract of P. glomerata roots, which is rich in pfaffosides, was inactive.
2.A new triterpene from Barringtonia asiatica.
Ragasa CY;Espineli DL;Shen CC Nat Prod Res. 2012;26(20):1869-75. Epub 2011 Sep 19.
The freeze-dried bark of Barringtonia asiatica afforded a new triterpene: (3β,11α)-11-hydroxyolean-12-en-3-yl palmitate (1). The bark also yielded mixtures of (3β)-olean-12-en-3-yl palmitate (2a), (3β)-urs-12-en-3-yl palmitate (2b) and (3β)-olean-18-en-3-yl palmitate (2c) in a 2:1:4 ratio; β-amyrin (3a), α-amyrin (3b) and germanicol (3c) in a 3:1:4 ratio; 22-O-tigloylcamelliagenin A (4a) and betulinic acid (4b) in a 2:1 ratio; olean-12-en-3β,16β,22α-triol (5), β-sitosterol, spinasterol, squalene and trilinolein. The roots yielded 2a-c and 3a-c as well as trilinolein, spinasterol and squalene, while the flowers afforded verimol k (6), linoleic acid, spinasterol, squalene, phytyl fatty acid ester and trilinolein. Compounds 1-4 and 6 were tested for antimicrobial property against seven microorganisms. All compounds tested exhibited slight activity against Candida albicans and were found inactive against Escherichia coli, Bacillus subtilis, Trichophyton mentagrophytes and Aspergillus niger. Except for the mixture of 4a and 4b that proved to be inactive, all the compounds were slightly active against the bacterium Staphylococcus aureus, while 3a-c were slightly active against Pseudomonas aeruginosa.
3.[Chemical constituents from the aerial part of Echinacea purpurea].
Chen QL;Wang L;Feng F Zhong Yao Cai. 2013 May;36(5):739-43.
OBJECTIVE: ;To study the chemical constituents of the aerial part of Echinacea purpurea.;METHODS: ;The compounds were separated and purified by repeatedly silica gel, ODS, D101 macroporous resin, MCI, Sephadex LH-20 column chromatography and recrystallization. Their structures were elucidated on the basis of physiochemical properties and spectral analysis.;RESULTS: ;Sixteen compounds were isolated and identified as (2S)-1-O-octacosanoyl glycerol (1), (5R,6S)-6-hydroxy-6-((E)-3-hydroxybut-1-enyl)-1,1, 5-trimethylcyclohexanone (2), (3S, 6E, 10R)-3, 10, 11-trihydroxy-3, 7, 11-trimethyl-dodeca-1, 6-diene (3), negunfurol (4), schensianol A (5), ent-4 (15) -eudesmene-1beta, 6alpha-diol (6), (E) -5-hydroxy-N-isobutylpentadec-2-enamide (7), syringaresinol (8), quercetin (9), ethyl laurate (10), ethyl caffeate (11), ferulic acid (12), alpha-spinasterol (13), stigmasterol (14), beta-daucosterol (15), octacosanoic acid (16).;CONCLUSION: ;Compound 1 - 5 are isolated from the Asteraceae for the first time, compound 6 ,7, 9, 10, 12 are isolated from genus of Echinacea for the first time, compound 15, 16 are isolated from this plant for the first time.
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CAS 481-18-5 α-Spinasterol

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