Spermidine trihydrochloride - CAS 334-50-9
Category: Inhibitor
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Molecular Formula:
C7H19N3.3HCl
Molecular Weight:
254.63
COA:
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Targets:
NMDA Receptor
Description:
Spermidine trihydrochloride is a polyamine that binds to NMDA receptor. Spermidine has been described as an agonist for its ability to enhance the binding of [3H]-MK801. It also acts as a NOS1 inhibitor.
Brife Description:
NMDA receptor agonist
Related CAS:
124-20-9 (free base)
Synonyms:
N-(3-Aminopropyl)-1,4-butanediamine trihydrochloride
MSDS:
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InChIKey:
LCNBIHVSOPXFMR-UHFFFAOYSA-N
InChI:
InChI=1S/C7H19N3.3ClH/c8-4-1-2-6-10-7-3-5-9;;;/h10H,1-9H2;3*1H
Canonical SMILES:
C(CCNCCCN)CN.Cl.Cl.Cl
1.Pulse laser-induced fragmentation of carbon quantum dots: a structural analysis.
Chu HW;Mao JY;Lien CW;Hsu PH;Li YJ;Lai JY;Chiu TC;Huang CC Nanoscale. 2017 Nov 30;9(46):18359-18367. doi: 10.1039/c7nr07639h.
Carbon quantum dots (CQDs) have attracted enormous interest in recent years owing to their low cytotoxicity, excellent biocompatibility and strong fluorescence. They have been successfully employed in sensor, bio-imaging, and drug carrier applications. A complete understanding of their core-surface structure is essential for tuning their physical and chemical properties for various applications. Conventional characterizations of CQDs are conducted with electron microscopy or spectroscopy, such as transmission electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy and Raman spectroscopy. However, these techniques cannot fully resolve the core-surface structure of CQDs. In this study, we attempt to analyze the structures of CQDs by laser desorption/ionization mass spectrometry (LDI-MS) using three model CQDs synthesized from citric acid (CA-CQDs), diammonium citrate (AC-CQDs) and spermidine trihydrochloride (Spd-CQDs). Both CA-CQDs and AC-CQDs produced anionic carbon cluster ions ([C;n;];-;, n = 4-9) during the laser desorption/ionization process. Additionally, AC-CQDs produced fragments containing C, N, and O that appeared at m/z values of 41.999, 91.
2.Gene silencing in root lesion nematodes (Pratylenchus spp.) significantly reduces reproduction in a plant host.
Tan JA;Jones MG;Fosu-Nyarko J Exp Parasitol. 2013 Feb;133(2):166-78. doi: 10.1016/j.exppara.2012.11.011. Epub 2012 Nov 29.
Root lesion nematodes (RLNs, Pratylenchus species) are a group of economically important migratory endoparasitic plant pathogens that attack host roots of major crops such as wheat and sugarcane, and can reduce crop yields by 7-15%. Pratylenchus thornei and Pratylenchus zeae were treated with double stranded RNA (dsRNA) to study gene silencing, (RNA interference, RNAi), as a potential strategy for their control. Mixed stages of nematodes of both species ingested dsRNA when incubated in a basic soaking solution in the presence of the neurostimulant octopamine. Incubation for up to 16 h in soaking solutions containing 10-50 mM octopamine, 0.1-1.0 mg/mL FITC, and 0.5-6 mM spermidine did not affect vitality. Spermidine phosphate salt hexahydrate rather than spermidine or spermidine trihydrochloride increased uptake of FITC by nematodes, and this resulted in more effective gene silencing. Silencing pat-10 and unc-87 genes of P. thornei and P. zeae resulted in paralysis and uncoordinated movements in both species, although to a higher degree in P. thornei. There was also a greater reduction in transcript of both genes in P. thornei indicating that it may be more susceptible to RNAi. For P.
3.The biosynthetic pathway of new polyamines in Caldariella acidophila.
De Rosa M;De Rosa S;Gambacorta A;Cartenì-Farina M;Zappia V Biochem J. 1978 Oct 15;176(1):1-7.
1. Spermidine and sym-nor-spermine (1,11-diamino-4,8-diazaundecane) were identified as the major components of the polyamine pool in Caldariella acidophila, an extreme thermoacidophilic bacterium. A minor component, a new polyamine, sym-nor-spermidine (1,7-diamino-4-azaheptane) was isolated and characterized. 2. To elucidate the biosynthetic pathway, labelled methionine, putrescine, spermidine and spermine were fed to Caldariella acidophila. Incubation of the bacterium in the presence of putrescine or spermidine labelled in the tetramethylene moiety gave unlabelled sym-nor-spermidine and sym-nor-spermine, whereas the radioactivity of propylamine-labelled methionine or spermidine was incorporated into these molecules. No radioactivity was recovered in the polyamines pool when spermine was fed to Caldariella acidophila. 3. S-Adenosylmethionine and S-(5'-adenosyl)-3-methylthiopropylamine were identified as intermediates of the biosynthetic pathway; the cellular contents of the two sulphonium compounds, measured with a new isotope-dilution technique, are 60 and 15nmol/g wet wt. of cells respectively. 4. The above results are indicative of a new pathway characterized by three propylamine-transfer reactions, decarboxylated S-adenosylmethionine being the common donor of the propylamine moiety.
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CAS 334-50-9 Spermidine trihydrochloride

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