SPD 304 - CAS 869998-49-2
Category: Inhibitor
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Molecular Formula:
C32H32F3N3O2.2HCl
Molecular Weight:
620.53
COA:
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Targets:
TNF-alpha
Description:
SPD 304 a cell-permeable inhibitor of tumor necrosis factor-α (TNFα, IC50 = 22 μM), which is a modulator of inflammation conditions such as rheumatoid arthritis, toxic shock, and sepsis. SPD 304 binids to TNFα trimer and promotes accelerated displacement of a single subunit to rapidly inactivate the cytokine. It inhibits TNF-α-induced IkB-α depletion in HeLa cells (IC50 = 4.6 μM).
Brife Description:
TNFα inhibitor
Purity:
99%
Synonyms:
SPD-304, SPD 304, SPD304. 6,7-dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-one; CAY10500
MSDS:
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Application:
anti-inflammatory agent
InChIKey:
JZNXLPPJRFFECJ-UHFFFAOYSA-N
InChI:
InChI=1S/C32H32F3N3O2/c1-21-14-28-30(15-22(21)2)40-20-24(31(28)39)18-37(4)13-12-36(3)17-23-19-38(29-11-6-5-10-27(23)29)26-9-7-8-25(16-26)32(33,34)35/h5-11,14-16,19-20H,12-13,17-18H2,1-4H3
Canonical SMILES:
CC1=C(C=C2C(=C1)C(=O)C(=CO2)CN(C)CCN(C)CC3=CN(C4=CC=CC=C43)C5=CC=CC(=C5)C(F)(F)F)C
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CAS 869998-49-2 SPD 304

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